The pathophysiological mechanism of hepatic fibrosis (HF) is related to the excessive
activation of the DNA repair enzyme poly ADP-ribose polymerase-1 (PARP-1). The drugs …

Background: Penthorum chinense Pursh (PCP) is widely utilized in China to treat a variety of
liver diseases. It has been shown that flavonoids inhibit inflammation and have the potential …

Liver fibrosis, a chronic inflammatory healing reaction, progresses to hepatocirrhosis without
effective intervention. Hesperetin derivative (HD-16), a monomer compound derived from …

Liver damage and fibrosis are serious health problems without effective treatment.
Proanthocyanidins (PAs) are flavonoids with several biological effects. We investigated the …

Oxidative stress plays a critical role in the development of liver disease, making antioxidants
a promising therapeutic approach for the prevention and management of liver injuries. The …

Liver fibrosis involves several signalling pathways working in concert regulating the
deposition of extracellular matrix. In this study, we evaluated the effect of quercetin and …

This study was designed to evaluate the potential effects of puerarin (PR), an effective
isoflavonoid compound purified from Pueraria lobata, in treating hepatic fibrosis (HF) rats …

Hepatic fibrosis, a common pathological feature and leading cause of various chronic liver
diseases, still lacks effective therapy. Hesperetin derivative (HD) is a derivative of Traditional …

Liver fibrosis is a histological change that often occurs due to hepatic stellate cell (HSC)
activation and excessive formation of an extracellular matrix in the liver. Pelargonidin (PEL) …

Quercetin, a natural flavonoid, has been used as a nutritional supplement for its anti-
inflammatory and antioxidative properties. Quercetin was reported to exhibit a wide range of …