The regulation of brain cytochrome P450 enzymes (CYPs) is different compared with
respective hepatic enzymes. This may result from anatomical bases and physiological …

Cytochrome P450 (CYP) enzymes are responsible for the metabolism of many exogenous
and endogenous compounds. CYPs are abundant in the liver and are also expressed in …

Cytochrome P450 (CYP) enzymes in the brain may have a role in the activation or
inactivation of centrally acting drugs, in the metabolism of endogenous compounds, and in …

Cytochrome P450 (CYP, P450) is the collective term for a superfamily of heme-containing
membrane proteins responsible for the metabolism of∼ 70-80% of clinically used drugs …

The metabolism of xenobiotics in human brain constitutes a field of recent intensive research
in relation to the potential implications in the pharmacological effect of drugs acting on the …

The importance of cytochrome P450 (CYP) 3A enzymes in human drug metabolism is well
established. The function of these enzymes has been characterized extensively in liver and …

Highlights•Brain P450 enzymes constitute an extra-hepatic line of drug metabolism.•P450s
expressed in brain cells contribute to neurotoxicity or neuroprotection.•Neurovascular P450 …

Drug metabolism is traditionally thought of as a function of the liver. Although this remains
essentially true, there is now evidence that drug-metabolizing enzymes are also located in …

Cytochromes P450 (CYPs) constitute a family of enzymes that can be found in the
endoplasmic reticulum (ER), mitochondria or the cell surface of the cells. CYPs are …

Individuals vary in their response to centrally acting drugs, and this is not always predicted
by drug plasma levels. Central metabolism by brain cytochromes P450 (CYPs) may …