Iron is essential for many cellular processes, but cellular iron homeostasis must be
maintained to ensure the balance of cellular signaling processes and prevent disease. Iron …

Mitoferrin 1 and mitoferrin 2 are homologous members of the mitochondrial solute carrier
family. Mitoferrin 1 is required for mitochondrial iron delivery in developing erythrocytes …

Iron is universally important to cellular metabolism, and mitoferrin-1 and-2 have been
proposed to be the iron importers of mitochondria, the cell's assembly plant of heme and iron …

The mitochondrion is well known for its key role in energy transduction. However, it is less
well appreciated that it is also a focal point of iron metabolism. Iron is needed not only for …

Pathological overload of iron in the mitochondrial matrix has been observed in numerous
diseases, including sideroblastic anemias, which have many causes, and in genetic …

The mitochondrion plays vital roles in various aspects of cellular metabolism, ranging from
energy transduction and apoptosis to the synthesis of important molecules such as heme …

Cellular iron homeostasis and mitochondrial iron homeostasis are interdependent.
Mitochondria must import iron to form iron–sulfur clusters and heme, and to incorporate …

Mitochondrial iron import is essential for iron–sulfur cluster formation and heme
biosynthesis. Two nuclear-encoded vertebrate mitochondrial high-affinity iron importers …

Iron is essential for organisms. It is mainly utilized in mitochondria for biosynthesis of iron-
sulfur clusters, hemes and other cofactors. Mitoferrin 1 and mitoferrin 2, two homologues …

Iron is a crucial transition metal for virtually all life. Two major destinations of iron within
mammalian cells are the cytosolic iron-storage protein, ferritin, and mitochondria. In …