Mitoferrin-1 (Mfrn1; Slc25a37), a member of the solute carrier family localized in the
mitochondrial inner membrane, functions as an essential iron importer for the synthesis of …

Mitochondrial function depends on iron-containing enzymes and proteins, whose maturation
requires available iron for biosynthesis of iron–sulfur clusters and heme. Little is known …

Iron is one of the most important elements for life, but excess iron is toxic. Intracellularly,
mitochondria are the center of iron utilization requiring sufficient amounts to maintain normal …

Systemic iron homeostasis needs to be tightly controlled, as both deficiency and excess iron
cause major global health concerns, such as iron deficiency anemia, hemochromatosis, etc …

Iron is a critical metal for several vital biological processes. Most of the body's iron is bound
to hemoglobin in erythrocytes. Iron from senescent red blood cells is recycled by …

Cytosolic ferritin sequesters and stores iron and, consequently, protects cells against iron-
mediated free radical damage. However, the function of the newly discovered mitochondrial …

Introduction: Mitochondria are cellular organelles that perform numerous bioenergetic,
biosynthetic, and regulatory functions and play a central role in iron metabolism …

Mitochondrial function depends on a continuous supply of iron to the iron− sulfur cluster
(ISC) and heme biosynthetic pathways as well as on the ability to prevent iron-catalyzed …

Iron is an essential element for metabolic processes intrinsic to life, and yet the properties
that make iron a necessity also make it potentially deleterious. To avoid harm, iron …

Mitochondria are an iconic distinguishing feature of eukaryotic cells. Mitochondria
encompass an active organellar network that fuses, divides, and directs a myriad of vital …