EGFR mutations are detected comparably in cytologic and surgical pathology specimens of nonsmall cell lung cancer

JH Smouse, ES Cibas, PA Jänne… - … : A Journal of the …, 2009 - Wiley Online Library
BACKGROUND: Somatic mutations in the epidermal growth factor receptor (EGFR) are
present in∼ 10% of nonsmall cell lung cancers, and higher in never‐smokers, women, and …

EGFR mutation testing in lung cancer: a review of available methods and their use for analysis of tumour tissue and cytology samples

G Ellison, G Zhu, A Moulis, S Dearden… - Journal of clinical …, 2013 - jcp.bmj.com
Aims Activating mutations in the gene encoding epidermal growth factor receptor (EGFR)
can confer sensitivity to EGFR tyrosine kinase inhibitors such as gefitinib in patients with …

High concordance of EGFR mutation status between histologic and corresponding cytologic specimens of lung adenocarcinomas

PL Sun, Y Jin, H Kim, CT Lee, S Jheon… - Cancer …, 2013 - Wiley Online Library
BACKGROUND Activating mutations in the epidermal growth factor receptor (EGFR) in non–
small cell lung carcinoma (NSCLC) are associated significantly with responsiveness to …

[HTML][HTML] Detection of EGFR mutation status in lung adenocarcinoma specimens with different proportions of tumor cells using two methods of differential sensitivity

HS Han, S Lim, JY An, KM Lee, KH Choe… - Journal of thoracic …, 2012 - Elsevier
Introduction: To evaluate epidermal growth factor receptor (EGFR) mutation status in lung
adenocarcinoma specimens with different proportions of tumor cells using two methods with …

[HTML][HTML] Tissue heterogeneity of EGFR mutation in lung adenocarcinoma

A Sakurada, H Lara-Guerra, N Liu, FA Shepherd… - Journal of Thoracic …, 2008 - Elsevier
Tissue heterogeneity of EGFR gene mutation was studied in 10 formalin-fixed paraffin-
embedded (FFPE) samples from four cases that demonstrated EGFR mutations in snap …

[HTML][HTML] Clinicopathologic characteristics of the EGFR gene mutation in non–small cell lung cancer

AS Tsao, XM Tang, B Sabloff, L Xiao… - Journal of Thoracic …, 2006 - Elsevier
Background The authors sought to define clinicopathologic features associated with
mutations of the epidermal growth factor receptor (EGFR) gene in non–small cell lung …

EGFR mutations in lung adenocarcinomas: clinical testing experience and relationship to EGFR gene copy number and immunohistochemical expression

AR Li, D Chitale, GJ Riely, W Pao, VA Miller… - The Journal of Molecular …, 2008 - Elsevier
Lung adenocarcinomas responsive to epidermal growth factor receptor (EGFR) tyrosine
kinase inhibitors possess EGFR mutations and often increased EGFR copy number. We …

EGFR and KRAS mutations in lung carcinoma Molecular testing by using cytology specimens

S Billah, J Stewart, G Staerkel, S Chen… - Cancer …, 2011 - Wiley Online Library
BACKGROUND: The aim of this study was to validate clinical utilization of routinely prepared
cytology specimens for molecular testing to detect EGFR or KRAS mutations in lung cancer …

[HTML][HTML] Detection of EGFR gene mutations in non-small cell lung cancer: lessons from a single-institution routine analysis of 1,403 tumor samples

A Vallee, C Sagan, AG Le Loupp… - International …, 2013 - spandidos-publications.com
Activating mutations of the epidermal growth factor receptor (EGFR) in lung tumors are
associated with a dramatic response to tyrosine kinase inhibitors. Therefore, routine analysis …

Evaluation of denaturing high‐performance liquid chromatography as a rapid detection method for identification of epidermal growth factor receptor mutations in …

V Cohen, JS Agulnik, J Jarry, G Batist, D Small… - Cancer, 2006 - Wiley Online Library
BACKGROUND. Somatic mutations of the epidermal growth factor receptor (EGFR) gene in
nonsmall‐cell lung cancer (NSCLC) may predict responsiveness to tyrosine kinase …