The A2AR is largely coexpressed with D2Rs and enkephalin mRNA in the striatum where it
modulates dopaminergic activity. Activation of the A2AR antagonizes D2R-mediated …

Dopamine D2 receptors (Rs) and adenosine A2ARs are coexpressed on striatopallidal
neurons, where they mediate opposing actions. In agreement with the idea that D2Rs …

In Parkinson's disease a degeneration of dopaminergic neurons of the nigrostriatal pathway
is observed. Loss of dopaminergic regulation of striatal neuron activity results in altered …

The possible molecular basis for the previously described antagonistic interactions between
adenosine A1 receptors (A1R) and dopamine D1 receptors (D1R) in the brain have been …

Adenosine A2A and dopamine D2 receptors have been shown previously to form
heteromeric complexes and interact at the level of agonist binding, G protein coupling, and …

Adenosine can influence dopaminergic neuro‐transmission in the basal ganglia via
postsynaptic inter‐action between adenosine A2A and dopamine D2 receptors. We have …

A2A adenosine receptors are highly expressed in the striatum where they modulate
dopaminergic activity. The role of A2A receptors in psychostimulant action is less well …

A cDNA fragment homologous to other G protein-coupled receptors was isolated from rat
brain using the PCR method and demonstrated to be abundantly expressed in striatum …

Adenosine acts as a neuromodulator through A1 and A2 receptors. The adenosine analogs
have been recognized, among other effects, as strong depressors of the locomotor activity …

Since high-affinity adenosine A2 receptors (A2a) are localized exclusively in dopamine-rich
regions in the central nervous system and mediate inhibition of locomotor activity, we have …