Novel genetic loci affecting facial shape variation in humans

Z Xiong, G Dankova, LJ Howe, MK Lee, PG Hysi… - elife, 2019 - elifesciences.org
The human face represents a combined set of highly heritable phenotypes, but knowledge
on its genetic architecture remains limited, despite the relevance for various fields. A series …

Genome-wide mapping of global-to-local genetic effects on human facial shape

P Claes, J Roosenboom, JD White, T Swigut, D Sero… - Nature …, 2018 - nature.com
Genome-wide association scans of complex multipartite traits like the human face typically
use preselected phenotypic measures. Here we report a data-driven approach to …

Insights into the genetic architecture of the human face

JD White, K Indencleef, S Naqvi, RJ Eller, H Hoskens… - Nature …, 2021 - nature.com
The human face is complex and multipartite, and characterization of its genetic architecture
remains challenging. Using a multivariate genome-wide association study meta-analysis of …

A genome-wide association study identifies five loci influencing facial morphology in Europeans

F Liu, F Van Der Lijn, C Schurmann, G Zhu… - 2012 - journals.plos.org
Inter-individual variation in facial shape is one of the most noticeable phenotypes in
humans, and it is clearly under genetic regulation; however, almost nothing is known about …

Genetic variants underlying differences in facial morphology in East Asian and European populations

M Zhang, S Wu, S Du, W Qian, J Chen, L Qiao… - Nature Genetics, 2022 - nature.com
Facial morphology—a conspicuous feature of human appearance—is highly heritable.
Previous studies on the genetic basis of facial morphology were performed mainly in …

Decoding the human face: progress and challenges in understanding the genetics of craniofacial morphology

S Naqvi, H Hoskens, F Wilke… - Annual review of …, 2022 - annualreviews.org
Variations in the form of the human face, which plays a role in our individual identities and
societal interactions, have fascinated scientists and artists alike. Here, we review our current …

A GWAS in Latin Americans identifies novel face shape loci, implicating VPS13B and a Denisovan introgressed region in facial variation

B Bonfante, P Faux, N Navarro, J Mendoza-Revilla… - Science …, 2021 - science.org
To characterize the genetic basis of facial features in Latin Americans, we performed a
genome-wide association study (GWAS) of more than 6000 individuals using 59 landmark …

Genome scans of facial features in East Africans and cross-population comparisons reveal novel associations

C Liu, MK Lee, S Naqvi, H Hoskens, D Liu… - PLoS …, 2021 - journals.plos.org
Facial morphology is highly variable, both within and among human populations, and a
sizable portion of this variation is attributable to genetics. Previous genome scans have …

Genome-wide association study reveals multiple loci influencing normal human facial morphology

JR Shaffer, E Orlova, MK Lee, EJ Leslie… - PLoS …, 2016 - journals.plos.org
Numerous lines of evidence point to a genetic basis for facial morphology in humans, yet
little is known about how specific genetic variants relate to the phenotypic expression of …

Human facial shape and size heritability and genetic correlations

JB Cole, M Manyama, JR Larson, DK Liberton… - Genetics, 2017 - academic.oup.com
The human face is an array of variable physical features that together make each of us
unique and distinguishable. Striking familial facial similarities underscore a genetic …