Synaptic dysfunction is implicated in the pathophysiology of schizophrenia (SCZ) and
bipolar disorder (BP). We use quantitative mass spectrometry to carry out deep, unbiased …

Schizophrenia (SCZ) and bipolar disorder (BPD) are severe mental disorders with high
heritability. Clinicians have long noticed the similarities of clinic symptoms between these …

The postsynaptic density (PSD) contains a complex set of proteins of known relevance to
neuropsychiatric disorders, and schizophrenia specifically. We enriched for this anatomical …

Background Neuropsychiatric disorders such as Schizophrenia (SCZ) and Bipolar disorder
(BPD) pose a broad range of problems with different symptoms mainly characterized by …

Background Synapses are fundamental components of brain circuits and are disrupted in
over 100 neurological and psychiatric diseases. The synapse proteome is physically …

Importance Findings from unbiased genetic studies have consistently implicated synaptic
protein networks in schizophrenia, but the molecular pathologic features within these …

Proteome modifications downstream of monogenic or polygenic disorders have the potential
to uncover novel molecular mechanisms participating in pathogenesis and/or extragenic …

Abstract Schizophrenia (SZ), bipolar disorder (BD), and major depressive disorder (MDD)
are major mental disorders that affect a significant proportion of the global population …

The molecular mechanisms of major mental illnesses, such as schizophrenia and bipolar
disorder, are unclear. To address this fundamental question, many groups have studied …

Schizophrenia is a psychiatric disorder that affects 21 million people worldwide. Despite
several studies having been shown that some brain regions may play a critical role in the …