Pain is the main symptom of osteoarthritis, which severely reduces the patients' quality of
life. Stimulated neuroinflammation and elevated mitochondrial oxidative stress are …

Bone is the preferential site of metastasis for breast cancer. Invasion of cancer cells induces
the destruction of bone tissue and damnification of peripheral nerves and consequently …

Chronic pain is the key manifestations of rheumatoid arthritis. Neuroinflammation in the
spinal cord drives central sensitization and chronic pain. Ferroptosis has potentially …

We sought to determine whether TDZD‐8, the inhibitor of the glycogen synthase kinase‐3β
(GSK3β), can protect the synovial membrane of the knee joint against injuries induced by …

Rheumatoid arthritis (RA) displays very similar characteristics to those of tumor cells,
platycodin D (PD) is a triterpenoid saponin abundant in Platycodon grandiflorum (PG), plays …

Chronic pain is the most common symptom for people who suffer from rheumatoid arthritis
and it affects approximately 1% of the global population. Neuroinflammation in the spinal …

Chronic pain is the primary symptom of osteoarthritis affecting a patient's quality of life.
Neuroinflammation and oxidative stress in the spinal cord contribute to arthritic pain and …

Chronic pain is the predominant problem for rheumatoid arthritis patients, and negatively
affects quality of life. Arthritis pain management remains largely inadequate, and developing …

Osteoarthritis (OA) is a major cause of cartilage pain and limited mobility in middle-aged and
elderly individuals. The degeneration of cartilage induced by inflammation and cartilage …

Purpose: Osteoarthritis (OA) is the most common degenerative joint disease in the aged
population affecting millions throughout the globe. Pharmacological induction of …