Hyperoxia-induced S1P1 signaling reduced angiogenesis by suppression of TIE-2 leading to experimental bronchopulmonary dysplasia
T Sudhadevi, A Jafri, AW Ha, P Basa… - Cell biochemistry and …, 2021 - Springer
Introduction We have earlier shown that hyperoxia (HO)-induced sphingosine kinase 1
(SPHK1)/sphingosine-1-phosphate (S1P) signaling contribute to bronchopulmonary …
(SPHK1)/sphingosine-1-phosphate (S1P) signaling contribute to bronchopulmonary …
[HTML][HTML] Sphingosine kinase 1 deficiency confers protection against hyperoxia-induced bronchopulmonary dysplasia in a murine model: role of S1P signaling and Nox …
A Harijith, S Pendyala, NM Reddy, T Bai… - The American journal of …, 2013 - Elsevier
Bronchopulmonary dysplasia of the premature newborn is characterized by lung injury,
resulting in alveolar simplification and reduced pulmonary function. Exposure of neonatal …
resulting in alveolar simplification and reduced pulmonary function. Exposure of neonatal …
[HTML][HTML] Expression profiling of genes regulated by sphingosine kinase1 signaling in a murine model of hyperoxia induced neonatal bronchopulmonary dysplasia
V Natarajan, AW Ha, Y Dong, NM Reddy, DL Ebenezer… - BMC genomics, 2017 - Springer
Abstract Background Sphingosine-1-Phosphate (S1P) is a bioactive lipid and an
intracellular as well as an extracellular signaling molecule. S1P ligand specifically binds to …
intracellular as well as an extracellular signaling molecule. S1P ligand specifically binds to …
[HTML][HTML] Hypoxia induces pulmonary arterial fibroblast proliferation, migration, differentiation and vascular remodeling via the PI3K/Akt/p70S6K signaling pathway
X Chai, D Sun, Q Han, L Yi… - … journal of molecular …, 2018 - spandidos-publications.com
The present study was designed to examine whether hypoxia induces the proliferation,
migration and differentiation of pulmonary arterial fibroblasts (PAFs) via the …
migration and differentiation of pulmonary arterial fibroblasts (PAFs) via the …
Neonatal therapy with PF543, a sphingosine kinase 1 inhibitor, ameliorates hyperoxia-induced airway remodeling in a murine model of bronchopulmonary dysplasia
AW Ha, T Sudhadevi, DL Ebenezer… - … of Physiology-Lung …, 2020 - journals.physiology.org
Hyperoxia (HO)-induced lung injury contributes to bronchopulmonary dysplasia (BPD) in
preterm newborns. Intractable wheezing seen in BPD survivors is associated with airway …
preterm newborns. Intractable wheezing seen in BPD survivors is associated with airway …
Sphingosine kinase 1 regulates lysyl oxidase through STAT3 in hyperoxia-mediated neonatal lung injury
AW Ha, T Bai, DL Ebenezer, T Sethi, T Sudhadevi… - Thorax, 2022 - thorax.bmj.com
Introduction Neonatal lung injury as a consequence of hyperoxia (HO) therapy and ventilator
care contribute to the development of bronchopulmonary dysplasia (BPD). Increased …
care contribute to the development of bronchopulmonary dysplasia (BPD). Increased …
[HTML][HTML] Sphingosine kinase 1 deficiency in smooth muscle cells protects against hypoxia-mediated pulmonary hypertension via YAP1 signaling
J Chen, A Lockett, S Zhao, LS Huang, Y Wang… - International journal of …, 2022 - mdpi.com
Sphingosine kinase 1 (SPHK1) and the sphingosine-1-phosphate (S1P) signaling pathway
have been shown to play a role in pulmonary arterial hypertension (PAH). S1P is an …
have been shown to play a role in pulmonary arterial hypertension (PAH). S1P is an …
Sphingosine kinase 1 deficiency protects bleomycin induced mouse lung fibrosis
longshuang huang, P Fu, W Ma, D He… - A69. LIPID …, 2011 - atsjournals.org
Idiopathic pulmonary fibrosis (IPF) is characterized by alveolar epithelial cell injury, areas of
type II cell hyperplasia, accumulation of fibroblasts and myofibroblasts, and the deposition of …
type II cell hyperplasia, accumulation of fibroblasts and myofibroblasts, and the deposition of …
Hyperoxia-induced p47phox activation and ROS generation is mediated through S1P transporter Spns2, and S1P/S1P1&2 signaling axis in lung endothelium
A Harijith, S Pendyala, DL Ebenezer… - … of Physiology-Lung …, 2016 - journals.physiology.org
Hyperoxia-induced lung injury adversely affects ICU patients and neonates on ventilator
assisted breathing. The underlying culprit appears to be reactive oxygen species (ROS) …
assisted breathing. The underlying culprit appears to be reactive oxygen species (ROS) …
[HTML][HTML] Hyperoxia disrupts extracellular signal-regulated kinases 1/2-induced angiogenesis in the developing lungs
RT Menon, AK Shrestha, R Barrios… - International journal of …, 2018 - mdpi.com
Hyperoxia contributes to the pathogenesis of bronchopulmonary dysplasia (BPD), a chronic
lung disease of infants that is characterized by interrupted alveologenesis. Disrupted …
lung disease of infants that is characterized by interrupted alveologenesis. Disrupted …