The role of photodynamic therapy in posterior fossa brain tumors: A preclinical study in a canine glioma model

HT Whelan, MH Schmidt, AD Segura… - Journal of …, 1993 - thejns.org
✓ Photodynamic therapy was studied in dogs with and without posterior fossa
glioblastomas. This mode of therapy consisted of intravenous administration of Photofrin-II at …

Photodynamic therapy of malignant brain tumors: clinical and neuropathological results

H Kostron, G Weiser, E Fritsch… - Photochemistry and …, 1987 - Wiley Online Library
Fourteen patients with malignant brain tumors were treated 17 times with photodynamic
treatment following either intravenous, selective intraarterial or direct intratumoral injection of …

Toxicity of photodynamic therapy with photofrin in the normal rat brain

Y Ji, SK Powers, JT Brown, D Walstad… - Lasers in surgery and …, 1994 - Wiley Online Library
The widespread acceptance of photodynamic therapy (PDT), a potential adjuvant brain
tumor therapy under clinical evaluation since 1980, has been partially restrained by its …

Neuronal injury after photoactivation of photofrin II.

Y Yoshida, MO Dereski, JH Garcia… - The American journal …, 1992 - ncbi.nlm.nih.gov
Photodynamic therapy has been used in the management of patients with malignant brain
tumors even though the effects of this form of treatment on the adjacent normal brain are …

Improved survival from intracavitary photodynamic therapy of rat glioma

YJD Walstad, JT Brown… - Photochemistry and …, 1992 - Wiley Online Library
The effectiveness of intratumoral photoradiation in photodynamic therapy (PDT) using a
polyporphyrin photosensitizer was studied in the RT‐2 rat glioma model. One week after …

Photodynamic therapy of human glioma (U87) in the nude rat

M Chopp, L Madigan, M Dereski… - Photochemistry and …, 1996 - Wiley Online Library
We measured the response of normal brain and the human U87 glioma implanted in the
brain of rats (n= 65) to photodynamic therapy (PDT) using Photofrin as the sensitizer. Normal …

Experimental research photodynamic effects in perifocal, oedematous brain tissue

C Goetz, A Hasan, W Stummer, A Heimann… - Acta …, 2002 - Springer
Summary. Background: Photodynamic therapy (PDT) has been under discussion as
additional treatment option for malignant gliomas. However, damage not only to tumour …

Photofrin photodynamic therapy for malignant brain tumors

PJ Muller, BC Wilson, LD Lilge… - Optical Methods for …, 2001 - spiedigitallibrary.org
In a phase II trial we treated more than 100 patients with malignant brain tumors with 2-
mg/kg Photofrin iv. and intraoperative cavitary PDT. We concluded that PDT was safe in …

Photodynamic therapy using Photofrin in combination with buthionine sulfoximine (BSO) to treat 9L gliosarcoma in rat brain

F Jiang, L Lilge, M Belcuig, G Singh… - Lasers in Surgery …, 1998 - Wiley Online Library
Abstract Background and Objective: The reactive oxygen mechanisms associated with cell
damage after photodynamic therapy (PDT) may be exploited to enhance tumor destruction …

The Effect of Hypothermia and Hyperthermia on Photodynamic Therapy of Normal Brain: 141

MO Dereski, L Madigan, M Chopp - Neurosurgery, 1995 - journals.lww.com
Abstract THE EFFECT OF whole body hyperthermia and hypothermia in conjunction with
photodynamic therapy (PDT) was determined on normal rat brain. Hyperthermia animals …