First-in-human experience and acute procedural outcomes using a novel pulsed field ablation system: the PULSED AF pilot trial

A Verma, L Boersma, DE Haines, A Natale… - Circulation …, 2022 - Am Heart Assoc
Background: Pulsed field ablation (PFA) is a novel form of ablation using electrical fields to
ablate cardiac tissue. There are only limited data assessing the feasibility and safety of this …

Pulsed-field ablation-based pulmonary vein isolation: acute safety, efficacy and short-term follow-up in a multi-center real world scenario

MD Lemoine, T Fink, C Mencke, R Schleberger… - Clinical Research in …, 2023 - Springer
Purpose Pulsed-field ablation (PFA) is a new energy source to achieve pulmonary vein
isolation (PVI) by targeted electroporation of cardiomyocytes. Experimental and controlled …

Pulsed field ablation of paroxysmal atrial fibrillation: 1-year outcomes of IMPULSE, PEFCAT, and PEFCAT II

VY Reddy, SR Dukkipati, P Neuzil, A Anic, J Petru… - Clinical …, 2021 - jacc.org
Objectives This study sought to determine whether durable pulmonary vein isolation (PVI)
using pulsed field ablation (PFA) translates to freedom from atrial fibrillation recurrence …

Safety and effectiveness of pulsed field ablation to treat atrial fibrillation: one-year outcomes from the MANIFEST-PF registry

MK Turagam, P Neuzil, B Schmidt, T Reichlin… - Circulation, 2023 - Am Heart Assoc
Background: Pulsed field ablation is a novel nonthermal cardiac ablation modality using
ultra-rapid electrical pulses to cause cell death by a mechanism of irreversible …

Pulsed field ablation for pulmonary vein isolation in atrial fibrillation

VY Reddy, P Neuzil, JS Koruth, J Petru… - Journal of the American …, 2019 - jacc.org
Background: Catheter ablation of atrial fibrillation using thermal energies such as
radiofrequency or cryothermy is associated with indiscriminate tissue destruction. During …

Pulsed field ablation for the treatment of atrial fibrillation: PULSED AF pivotal trial

A Verma, DE Haines, LV Boersma, N Sood, A Natale… - Circulation, 2023 - Am Heart Assoc
Background: Pulsed field ablation uses electrical pulses to cause nonthermal irreversible
electroporation and induce cardiac cell death. Pulsed field ablation may have effectiveness …

Pulsed field ablation to treat atrial fibrillation: a review of the literature

A Di Monaco, N Vitulano, F Troisi, F Quadrini… - Journal of …, 2022 - mdpi.com
Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia and catheter
ablation, which can be used in symptomatic patients refractory to antiarrhythmic therapy …

Safety and chronic lesion characterization of pulsed field ablation in a Porcine model

MT Stewart, DE Haines, D Miklavčič… - Journal of …, 2021 - Wiley Online Library
Background Pulsed field ablation (PFA) has been identified as an alternative to thermal‐
based ablation systems for treatment of atrial fibrillation patients. The objective of this Good …

Pulsed‐field ablation combined with ultrahigh‐density mapping in patients undergoing catheter ablation for atrial fibrillation: practical and electrophysiological …

MA Gunawardene, BN Schaeffer… - Journal of …, 2022 - Wiley Online Library
Background Pulsed‐field ablation (PFA) yields a novel ablation technology for atrial
fibrillation (AF). PFA lesions promise to be highly durable, however clinical data on lesion …

Preclinical evaluation of pulsed field ablation: electrophysiological and histological assessment of thoracic vein isolation

J Koruth, K Kuroki, J Iwasawa, Y Enomoto… - Circulation …, 2019 - Am Heart Assoc
Background: Pulsed field ablation (PFA) is a uniquely tissue-selective, nonthermal cardiac
ablation modality. Delivery parameters such as the electrical waveform composition and …