Over the past years, advances in cancer immunotherapy have resulted in innovative and
novel approaches in molecular cancer diagnostics and cancer therapeutic procedures …

In-depth knowledge of cancer molecular and cellular mechanisms have revealed a strong
regulation of cancer development and progression by the inflammation which orchestrates …

Interleukins and associated cytokines serve as the means of communication for innate and
adaptive immune cells as well as non-immune cells and tissues. Thus, interleukins have a …

Cytokine-based immunotherapy is a promising field in the cancer treatment, since cytokines,
as proteins of the immune system, are able to modulate the host immune response toward …

Cytokines bind to specific receptors on target cells to activate intracellular signaling
pathways that control diverse cellular functions, such as proliferation, differentiation …

Background: Cytokines provide important intercellular signals in inflammation, immunity and
tumor and endothelial cell biology. Several cytokines have therapeutic potential when …

Immunotherapies including adaptive immune checkpoint inhibitors (ICIs) and chimeric
antigen receptor (CAR) T cells, have developed the treatment of cancer in clinic, and most of …

Cancers develop complex and dynamic tissue microenvironments to support their sustained
growth, invasion and metastasis. For decades, rapid progress has been made in the cross …

The cross talk between immune and non-immune cells in the tumor microenvironment leads
to immunosuppression, which promotes tumor growth and survival. Immunotherapy is an …

Cancer immunotherapy is demonstrating impressive clinical benefit in different malignancies
and clinical oncologists are increasingly turning their attention to immune-oncology. It is now …