Update on sepsis-associated acute kidney injury: emerging targeted therapies

JF Doyle, LG Forni - Biologics: Targets and Therapy, 2016 - Taylor & Francis
Sepsis-associated acute kidney injury (SA-AKI) is an independent predictor of increased
mortality and morbidity. It is essential that further advances in the treatment of sepsis should …

Sepsis-associated acute kidney injury

D Wang, T Sun, Z Liu - Intensive Care Research, 2023 - Springer
Sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host
immune response to infection. The kidneys are one of the first organs to be injured in sepsis …

Emerging therapeutic targets of sepsis-associated acute kidney injury

S Swaminathan, MH Rosner, MD Okusa - Seminars in nephrology, 2015 - Elsevier
Sepsis-associated acute kidney injury (SA-AKI) is linked to high morbidity and mortality. To
date, singular approaches to target specific pathways known to contribute to the …

Sepsis-associated acute kidney injury—treatment standard

A Zarbock, JL Koyner, H Gomez… - Nephrology Dialysis …, 2024 - academic.oup.com
Sepsis is a host's deleterious response to infection, which could lead to life-threatening
organ dysfunction. Sepsis-associated acute kidney injury (SA-AKI) is the most frequent …

Recent advances in the pharmacological management of sepsis-associated acute kidney injury

K Kalantari, MH Rosner - Expert Review of Clinical Pharmacology, 2021 - Taylor & Francis
Introduction Acute kidney injury is a common occurrence in patients with sepsis and
portends a high mortality as well as increased morbidity with numerous sequelae including …

[HTML][HTML] Acute kidney injury from sepsis: current concepts, epidemiology, pathophysiology, prevention and treatment

S Peerapornratana, CL Manrique-Caballero… - Kidney international, 2019 - Elsevier
Sepsis-associated acute kidney injury (S-AKI) is a frequent complication of the critically ill
patient and is associated with unacceptable morbidity and mortality. Prevention of S-AKI is …

Sepsis-associated acute kidney injury: recent advances in enrichment strategies, sub-phenotyping and clinical trials

M Legrand, SM Bagshaw, PK Bhatraju, A Bihorac… - Critical Care, 2024 - Springer
Acute kidney injury (AKI) often complicates sepsis and is associated with high morbidity and
mortality. In recent years, several important clinical trials have improved our understanding …

Novel therapeutic targets for prevention and therapy of sepsis associated acute kidney injury

CH Pelte, LS Chawla - Current drug targets, 2009 - ingentaconnect.com
Sepsis associated Acute Kidney Injury (SA-AKI) is the leading cause of AKI in the hospital
setting and its incidence is increasing. Although the exact pathophysiology and phenotype …

Sepsis-associated acute kidney injury: consensus report of the 28th Acute Disease Quality Initiative workgroup

A Zarbock, MK Nadim, P Pickkers, H Gomez… - Nature Reviews …, 2023 - nature.com
Sepsis-associated acute kidney injury (SA-AKI) is common in critically ill patients and is
strongly associated with adverse outcomes, including an increased risk of chronic kidney …

Potential interventions in sepsis-related acute kidney injury

C Ronco, JA Kellum, R Bellomo… - Clinical journal of the …, 2008 - journals.lww.com
Sepsis is an important cause of morbidity and mortality. Acute kidney injury often
complicates sepsis, leading to greater complexity, cost of care, and worsening prognosis. In …