Osteoarthritis is a chronic and painful disease of synovial joints. Chondrocytes, synovial
cells and other cells in the joint can express and respond to cytokines and chemokines, and …

The field of research on pain originating from various bone diseases is expanding rapidly,
with new mechanisms and targets asserting both peripheral and central sites of action. The …

This article introduces the scientific basis for the understanding of pain mechanisms and
highlights the importance of endogenous excitatory and inhibitory controls in the central …

The past few decades have witnessed a huge leap forward in our understanding of the
mechanistic underpinnings of pain, in normal states where it helps protect from injury, and …

In this narrative review, we discuss the emerging role of innate immunity in osteoarthritis
(OA) joint pain. First, we give a brief description of the pain pathway in the context of OA …

Pain in osteoarthritis (OA) remains an intractable problem in a majority of patients, with many
of the commonly prescribed analgesics providing insufficient relief and considerable side …

People with rheumatoid arthritis (RA) identify pain as their most important symptom, one that
often persists despite optimal control of inflammatory disease. RA pain arises from multiple …

Background Synovial inflammation is associated with pain severity in patients with knee
osteoarthritis (OA). The aim here was to determine in a population with knee OA, whether …

Abstract Purpose of Review Chronic pain in osteoarthritis (OA) is characterized by pain
sensitization, which involves both peripheral and central mechanisms. Studies suggest …

Objective OA is the most common joint disease, affecting 10–15% of people over 60 years of
age. However, up to 40% of individuals with radiologic damage are asymptomatic. The …