Modulation of CYP3A4 and CYP2C9 activity by Bulbine natalensis and its constituents: An assessment of HDI risk of B. natalensis containing supplements
Background Bulbine natalensis is an African-folk medicinal plant used as a dietary
supplement for enhancing sexual function and muscle strength in males by presumably …
supplement for enhancing sexual function and muscle strength in males by presumably …
Bulbine natalensis (currently Bulbine latifolia) and select bulbine knipholones modulate the activity of AhR, CYP1A2, CYP2B6, and P-gp
Bulbine natalensis, an emerging medicinal herb on the global market with androgenic
properties, is often formulated in dietary supplements that promote perceived sexual …
properties, is often formulated in dietary supplements that promote perceived sexual …
[HTML][HTML] In Vitro Reversible and Time-Dependent CYP450 Inhibition Profiles of Medicinal Herbal Plant Extracts Newbouldia laevis and Cassia abbreviata …
This study evaluated the effects of Newbouldia laevis and Cassia abbreviata extracts on
CYP450 enzyme activity. Recombinant CYP450 enzyme and fluorogenic substrates were …
CYP450 enzyme activity. Recombinant CYP450 enzyme and fluorogenic substrates were …
The interaction potential of herbal medicinal products: a luminescence-based screening platform assessing effects on cytochrome P450 and its use with devil's claw …
M Modarai, A Suter, A Kortenkamp… - Journal of pharmacy …, 2011 - academic.oup.com
Objectives Potential interactions between herbal medicinal products and the cytochrome
(CYP) P450 system are an important safety concern. We set out to develop a screening …
(CYP) P450 system are an important safety concern. We set out to develop a screening …
Suppression of beta-naphthoflavone induced CYP1A expression and lipid-peroxidation by berberine
W Chatuphonprasert, T Sangkawat, N Nemoto… - Fitoterapia, 2011 - Elsevier
Impacts of berberine, a major isoquinoline alkaloid in herbal plants, on beta-naphthoflavone
(BNF)-induced CYP1A expression were determined both in primary mouse hepatocytes and …
(BNF)-induced CYP1A expression were determined both in primary mouse hepatocytes and …
[HTML][HTML] Effect of an ethanol extract of Descurainia sophia seeds on Phase I and II drug metabolizing enzymes and P-glycoprotein activity in vitro
JM Yi, YA Kim, YJ Lee, OS Bang, NS Kim - BMC complementary and …, 2015 - Springer
Background Descurainia sophia seeds have a variety of pharmacological functions and
been widely used in traditional folk medicine. However, their effects on human drug …
been widely used in traditional folk medicine. However, their effects on human drug …
Risk assessment of the inhibition of hydroxygenkwanin on human and rat cytochrome P450 by cocktail method
J Gao, Y Zhang, X Lei, Y Xu, Z Sun, X Wang - Toxicology in Vitro, 2022 - Elsevier
Hydroxygenkwanin (HGK), a natural flavonoid extracted from the buds of Daphne genkwa
Sieb. et Zucc.(Thymelaeaceae), possesses a wide range of pharmacological activities …
Sieb. et Zucc.(Thymelaeaceae), possesses a wide range of pharmacological activities …
The inhibitory activity of the extracts of popular medicinal herbs on CYP1A2, 2C9, 2C19 and 3A4 and the implications for herb-drug interaction
PS Fasinu, PJ Bouic, B Rosenkranz - African journal of traditional …, 2014 - ajol.info
Background: Studies have suggested an increasing practice of concurrent herb-drug
consumption. One of the major clinical risks of such concomitant herb-drug use is …
consumption. One of the major clinical risks of such concomitant herb-drug use is …
[HTML][HTML] Evaluation of the impact of vindoline, an active components of Catharanthus roseus, on rat hepatic cytochrome P450 enzymes by using a cocktail of probe …
Y Zhang, H Niu, J Liu, W Xie, Y Jin, Z Zhang - Plos one, 2023 - journals.plos.org
The objection of this study was to investigate the effects of vindoline (VDL) on the
cytochrome P450 (CYP 450) isoforms (CYP1A2, 2B, 2C11, 2D1 and 3A) in rats. Firstly, the …
cytochrome P450 (CYP 450) isoforms (CYP1A2, 2B, 2C11, 2D1 and 3A) in rats. Firstly, the …
Evaluation of the impact of cantharidin on rat CYP enzymes by using a cocktail of probe drugs
C Zhou, L Qiao, L Zhao, Z Li - Fitoterapia, 2015 - Elsevier
The aim of this study was to assess the influence of cantharidin on the activities of the drug-
metabolizing enzymes CYP1A2, CYP2C9, CYP2C19, CYP2D6 and CYP3A4 in rats. The …
metabolizing enzymes CYP1A2, CYP2C9, CYP2C19, CYP2D6 and CYP3A4 in rats. The …