Fibroblasts play a pivotal role in cardiac remodeling and the development of heart failure
through the deposition of extra-cellular matrix (ECM) proteins and also by affecting …

Cardiac remodelling is a key risk factor for the development of heart failure in the chronic
phase following myocardial infarction. Our previous studies have shown an anti-remodelling …

Angiotensin-converting enzyme (ACE) 2 is a recently identified homologue of ACE. There is
great interest in the therapeutic benefit for ACE2 overexpression in the heart. However, the …

Angiotensin-converting enzyme 2 (ACE2) is present in the heart and thought to exert
protective functions. We conducted studies in ACE2 deficient mice to determine whether …

Heart failure (HF) remains the most common cause of death and disability, and a major
economic burden, in industrialized nations. Physiological, pharmacological, and clinical …

Cardiac remodeling, which typically results from chronic hypertension or following an acute
myocardial infarction, is a major risk factor for the development of heart failure and …

A novel angiotensin-converting enzyme (ACE) homolog, named ACE2, is a
monocarboxypeptidase which metabolizes several peptides. ACE2 degrades Angiotensin …

The cardiac renin–angiotensin–aldosterone system (RAAS) is an endocrine cascade, which
results in the conversion of the inactive pro-hormone angiotensin I (Ang I) to the active …

For decades, the literature has been inundated with evi-dence of the important role of the
renin–angiotensin system (RAS) in cardiac remodeling and function with most in the field …

The renin-angiotensin system (RAS) plays a major role in the pathophysiology of
cardiovascular disorders. Angiotensin II (Ang-II), the final product of this pathway, is known …