Immunoglobulin A (IgA), the major class of antibody secreted by the gut mucosa, is an
important contributor to gut barrier function,,. The repertoire of IgA bound to gut bacteria …

Dimeric IgA secreted across mucous membranes in response to nonpathogenic taxa of the
microbiota accounts for most antibody production in mammals. Diverse binding specificities …

The human distal gut harbours a vast ensemble of microbes (the microbiota) that provide
important metabolic capabilities, including the ability to extract energy from otherwise …

The proliferation of genetically modified mouse models has exposed phenotypic variation
between investigators and institutions that has been challenging to control,,,,. In many cases …

Cooperative phenotypes are considered central to the functioning of microbial communities
in many contexts, including communication via quorum sensing, biofilm formation, antibiotic …

The gut microbiota operates at the interface of host–environment interactions to influence
human homoeostasis and metabolic networks,,–. Environmental factors that unbalance gut …

Colonization by the microbiota causes a marked stimulation of B cells and induction of
immunoglobulin, but mammals colonized with many taxa have highly complex and …

Low concordance between studies that examine the role of microbiota in human diseases is
a pervasive challenge that limits the capacity to identify causal relationships between host …

The development of the microbiome from infancy to childhood is dependent on a range of
factors, with microbial–immune crosstalk during this time thought to be involved in the …

The largest mucosal surface in the body is in the gastrointestinal tract, a location that is
heavily colonized by microbes that are normally harmless. A key mechanism required for …