The blood–brain barrier (BBB) restricts entry of neurotoxic plasma components, blood cells,
and pathogens into the brain, leading to proper neuronal functioning. BBB impairment leads …

Amyloidogenicity and vascular dysfunction are the key players in the pathogenesis of
Alzheimer's disease (AD), involving dysregulated cellular interactions. An intricate balance …

Amyloid-β plaques and neurofibrillary tangles are the main neuropathological hallmarks in
Alzheimer's disease (AD), the most common cause of dementia in the elderly. However, it …

Alzheimer's disease (AD) is the leading cause of dementia worldwide. Most AD patients
develop the disease in late life, named late onset AD (LOAD). Currently, the most …

The intactness of blood–brain barrier (BBB) is compromised in Alzheimer's disease (AD).
Importantly, evidence suggests that the perturbation and abnormalities appearing in BBB …

Protein dyshomeostasis is the common mechanism of neurodegenerative diseases such as
Alzheimer's disease (AD). Aging is the key risk factor, as the capacity of the proteostasis …

Alzheimer's disease (AD) is a familiar neurodegenerative disease in the elderly. In this
paper, we will review current viewpoints of microglial activation, inflammatory regulatory …

Due to an increasingly aging population, Alzheimer disease (AD) represents a crucial issue
for the healthcare system because of its widespread prevalence and the burden of its care …

The goal of this paper is to provide scientists with a comprehensive review of the state-of-the-
art influence the ischemic blood–brain barrier (BBB) has on the final development of …

The incidence of dementia is increasing at an alarming rate, and has become a major public
health concern. Alzheimer disease (AD) is the most common form of dementia and is …