[HTML][HTML] The potential role of cytokines and growth factors in the pathogenesis of Alzheimer's disease

G Ogunmokun, S Dewanjee, P Chakraborty… - Cells, 2021 - mdpi.com
Alzheimer's disease (AD) is one of the most prominent neurodegenerative diseases, which
impairs cognitive function in afflicted individuals. AD results in gradual decay of neuronal …

[HTML][HTML] Blood-brain barrier dysfunction and Alzheimer's disease: associations, pathogenic mechanisms, and therapeutic potential

Y Chen, Y He, J Han, W Wei, F Chen - Frontiers in Aging …, 2023 - frontiersin.org
Alzheimer's disease (AD) is a common neurodegenerative disorder characterized by the
accumulation of amyloid-beta (Aβ), hyperphosphorylation of tau, and neuroinflammation in …

[HTML][HTML] Glutamate and GABA in microglia-neuron cross-talk in Alzheimer's disease

GA Czapski, JB Strosznajder - International Journal of Molecular Sciences, 2021 - mdpi.com
The physiological balance between excitation and inhibition in the brain is significantly
affected in Alzheimer's disease (AD). Several neuroactive compounds and their signaling …

[HTML][HTML] Discerning the role of blood brain barrier dysfunction in Alzheimer's disease

QQ Tao, RR Lin, YH Chen, ZY Wu - Aging and Disease, 2022 - ncbi.nlm.nih.gov
Alzheimer's disease (AD) is the most common form of neurodegenerative disease. The
predominant characteristics of AD are the accumulation of amyloid-β (Aβ) and …

Interactions between glial cells and the blood-brain barrier and their role in Alzheimer's disease

M Zhao, XF Jiang, HQ Zhang, JH Sun, H Pei… - Ageing research …, 2021 - Elsevier
Abstract Alzheimer's disease (AD), which is an irreversible neurodegenerative disorder
characterized by senile plaques and neurofibrillary tangles, is the most common form of …

[HTML][HTML] The neurovascular unit dysfunction in Alzheimer's disease

LO Soto-Rojas, M Pacheco-Herrero… - International Journal of …, 2021 - mdpi.com
Alzheimer's disease (AD) is the most common neurodegenerative disease worldwide.
Histopathologically, AD presents with two hallmarks: neurofibrillary tangles (NFTs), and …

Revealing the mechanisms of blood–brain barrier in chronic neurodegenerative disease: an opportunity for therapeutic intervention

S Yu, X Chen, T Yang, J Cheng, E Liu… - Reviews in the …, 2024 - degruyter.com
The brain microenvironment is tightly regulated, and the blood–brain barrier (BBB) plays a
pivotal role in maintaining the homeostasis of the central nervous system. It effectively …

[HTML][HTML] Peripheral pathways to neurovascular unit dysfunction, cognitive impairment, and Alzheimer's Disease

AR Nelson - Frontiers in aging neuroscience, 2022 - frontiersin.org
Alzheimer's disease (AD) is the most common form of dementia. It was first described more
than a century ago, and scientists are acquiring new data and learning novel information …

[HTML][HTML] Proteomic alterations in the brain and blood–brain barrier during brain Aβ accumulation in an APP knock-in mouse model of Alzheimer's disease

S Ito, R Yagi, S Ogata, T Masuda, T Saito… - Fluids and Barriers of …, 2023 - Springer
Background Blood–brain barrier (BBB) dysfunction is supposed to be an early event in the
development of Alzheimer's disease (AD). This study aimed to investigate the relationship …

[HTML][HTML] Microglia in the neuroinflammatory pathogenesis of Alzheimer's disease and related therapeutic targets

Y Cai, J Liu, B Wang, M Sun, H Yang - Frontiers in immunology, 2022 - frontiersin.org
Alzheimer's disease (AD) is the most prevalent neurodegenerative disease worldwide,
characterized by progressive neuron degeneration or loss due to excessive accumulation of …