A leaky blood–brain barrier, fibrinogen infiltration and microglial reactivity in inflamed Alzheimer's disease brain

JK Ryu, JG McLarnon - Journal of cellular and molecular …, 2009 - Wiley Online Library
This study has used immunohistochemical examination of tissue obtained from Alzheimer's
disease (AD) brains and rat hippocampus injected with Aβ1‐42 peptide to determine effects …

The role of extracellular matrix alterations in mediating astrocyte damage and pericyte dysfunction in Alzheimer's disease: A comprehensive review

MM Anwar, E Özkan… - European Journal of …, 2022 - Wiley Online Library
The brain is a highly vascularized tissue protected by the blood–brain barrier (BBB), a
complex structure allowing only necessary substances to pass through into the brain while …

[HTML][HTML] Addressing blood–brain barrier impairment in Alzheimer's disease

C Sharma, H Woo, SR Kim - Biomedicines, 2022 - mdpi.com
The blood–brain barrier (BBB) plays a vital role in maintaining the specialized
microenvironment of the brain tissue. It facilitates communication while separating the …

Dysfunction of the blood–brain barrier in Alzheimer's disease: evidence from human studies

C Kurz, L Walker, BS Rauchmann… - Neuropathology and …, 2022 - Wiley Online Library
The pathological processes leading to synapse loss, neuronal loss, brain atrophy and
gliosis in Alzheimer's disease (AD) and their relation to vascular disease and immunological …

Emerging Roles of Microglia in Blood-brain Barrier Integrity in Aging and Neurodegeneration

S Zhang, R Meng, M Jiang, H Qing… - Current …, 2024 - ingentaconnect.com
The blood-brain barrier (BBB) is a highly selective interface between the blood and the brain
parenchyma. It plays an essential role in maintaining a specialized environment for central …

Inflammatory mechanisms and oxidative stress as key factors responsible for progression of neurodegeneration: role of brain innate immune system

J Leszek, GE Barreto, K Gasiorowski… - CNS & Neurological …, 2016 - ingentaconnect.com
Chronic inflammation is characterized by longstanding microglial activation followed by
sustained release of inflammatory mediators, which aid in enhanced nitrosative and …

Mechanisms of cell signaling and inflammation in Alzheimer's disease

GJ Ho, R Drego, E Hakimian… - Current Drug Targets …, 2005 - ingentaconnect.com
Alzheimer's disease, the most common neurodegenerative dementia in the elderly, affects
cognition, behavior and functioning, and a prominent neuroinflammatory component likely …

[HTML][HTML] Elucidating the interactive roles of glia in Alzheimer's disease using established and newly developed experimental models

H Chun, I Marriott, CJ Lee, H Cho - Frontiers in Neurology, 2018 - frontiersin.org
Alzheimer's disease (AD) is an irreversible neurodegenerative illness and the exact etiology
of the disease remains unknown. It is characterized by long preclinical and prodromal …

Advances in the Understanding of the Correlation Between Neuroinflammation and Microglia in Alzheimer's Disease

H Yan, W Wang, T Cui, Y Shao, M Li… - ImmunoTargets and …, 2024 - Taylor & Francis
Alzheimer's disease (AD) is a fatal neurodegenerative disease with a subtle and progressive
onset and is the most common type of dementia. However, its etiology and pathogenesis …

[HTML][HTML] The molecular mechanisms of neuroinflammation in Alzheimer's disease, the consequence of neural cell death

SB Choi, S Kwon, JH Kim, NH Ahn, JH Lee… - International Journal of …, 2023 - mdpi.com
Alzheimer's disease (AD) is accompanied by neural cell loss and memory deficit. Neural cell
death, occurring via apoptosis and autophagy, is widely observed in the AD brain in addition …