A leaky blood–brain barrier, fibrinogen infiltration and microglial reactivity in inflamed Alzheimer's disease brain
JK Ryu, JG McLarnon - Journal of cellular and molecular …, 2009 - Wiley Online Library
This study has used immunohistochemical examination of tissue obtained from Alzheimer's
disease (AD) brains and rat hippocampus injected with Aβ1‐42 peptide to determine effects …
disease (AD) brains and rat hippocampus injected with Aβ1‐42 peptide to determine effects …
The role of extracellular matrix alterations in mediating astrocyte damage and pericyte dysfunction in Alzheimer's disease: A comprehensive review
MM Anwar, E Özkan… - European Journal of …, 2022 - Wiley Online Library
The brain is a highly vascularized tissue protected by the blood–brain barrier (BBB), a
complex structure allowing only necessary substances to pass through into the brain while …
complex structure allowing only necessary substances to pass through into the brain while …
[HTML][HTML] Addressing blood–brain barrier impairment in Alzheimer's disease
C Sharma, H Woo, SR Kim - Biomedicines, 2022 - mdpi.com
The blood–brain barrier (BBB) plays a vital role in maintaining the specialized
microenvironment of the brain tissue. It facilitates communication while separating the …
microenvironment of the brain tissue. It facilitates communication while separating the …
Dysfunction of the blood–brain barrier in Alzheimer's disease: evidence from human studies
C Kurz, L Walker, BS Rauchmann… - Neuropathology and …, 2022 - Wiley Online Library
The pathological processes leading to synapse loss, neuronal loss, brain atrophy and
gliosis in Alzheimer's disease (AD) and their relation to vascular disease and immunological …
gliosis in Alzheimer's disease (AD) and their relation to vascular disease and immunological …
Emerging Roles of Microglia in Blood-brain Barrier Integrity in Aging and Neurodegeneration
S Zhang, R Meng, M Jiang, H Qing… - Current …, 2024 - ingentaconnect.com
The blood-brain barrier (BBB) is a highly selective interface between the blood and the brain
parenchyma. It plays an essential role in maintaining a specialized environment for central …
parenchyma. It plays an essential role in maintaining a specialized environment for central …
Inflammatory mechanisms and oxidative stress as key factors responsible for progression of neurodegeneration: role of brain innate immune system
J Leszek, GE Barreto, K Gasiorowski… - CNS & Neurological …, 2016 - ingentaconnect.com
Chronic inflammation is characterized by longstanding microglial activation followed by
sustained release of inflammatory mediators, which aid in enhanced nitrosative and …
sustained release of inflammatory mediators, which aid in enhanced nitrosative and …
Mechanisms of cell signaling and inflammation in Alzheimer's disease
GJ Ho, R Drego, E Hakimian… - Current Drug Targets …, 2005 - ingentaconnect.com
Alzheimer's disease, the most common neurodegenerative dementia in the elderly, affects
cognition, behavior and functioning, and a prominent neuroinflammatory component likely …
cognition, behavior and functioning, and a prominent neuroinflammatory component likely …
[HTML][HTML] Elucidating the interactive roles of glia in Alzheimer's disease using established and newly developed experimental models
Alzheimer's disease (AD) is an irreversible neurodegenerative illness and the exact etiology
of the disease remains unknown. It is characterized by long preclinical and prodromal …
of the disease remains unknown. It is characterized by long preclinical and prodromal …
Advances in the Understanding of the Correlation Between Neuroinflammation and Microglia in Alzheimer's Disease
H Yan, W Wang, T Cui, Y Shao, M Li… - ImmunoTargets and …, 2024 - Taylor & Francis
Alzheimer's disease (AD) is a fatal neurodegenerative disease with a subtle and progressive
onset and is the most common type of dementia. However, its etiology and pathogenesis …
onset and is the most common type of dementia. However, its etiology and pathogenesis …
[HTML][HTML] The molecular mechanisms of neuroinflammation in Alzheimer's disease, the consequence of neural cell death
SB Choi, S Kwon, JH Kim, NH Ahn, JH Lee… - International Journal of …, 2023 - mdpi.com
Alzheimer's disease (AD) is accompanied by neural cell loss and memory deficit. Neural cell
death, occurring via apoptosis and autophagy, is widely observed in the AD brain in addition …
death, occurring via apoptosis and autophagy, is widely observed in the AD brain in addition …