Differential sensitivity of various human tumour-derived cell types to apoptosis by organic derivatives of selenium
RJ Jariwalla, B Gangapurkar… - British journal of nutrition, 2008 - cambridge.org
Selenium is an important trace element with anti-cancer properties. In the present study, the
apoptosis-inducing effects of organic selenium derivatives, namely methyl-l-selenocysteine …
apoptosis-inducing effects of organic selenium derivatives, namely methyl-l-selenocysteine …
Novel strategies in selenium cancer chemoprevention research
C Ip, HE Ganther - Selenium in biology and human health, 1994 - Springer
Experimental studies with rodents indicate that selenium supplementation at levels above
the dietary requirement is capable of protecting against tumorigenesis induced by chemical …
the dietary requirement is capable of protecting against tumorigenesis induced by chemical …
Selenium and selenocysteine: roles in cancer, health, and development
DL Hatfield, PA Tsuji, BA Carlson… - Trends in biochemical …, 2014 - cell.com
The many biological and biomedical effects of selenium are relatively unknown outside the
selenium field. This fascinating element, initially described as a toxin, was subsequently …
selenium field. This fascinating element, initially described as a toxin, was subsequently …
Mechanisms of selenium inhibition of tumorigenesis
D Medina - Journal of the American College of Toxicology, 1986 - journals.sagepub.com
INTRODUCTION s IP HAS DISCUSSED,(') selenium supplementation inhibits tumorigenesis
in a variety of organs A and species and under different dietary conditions. The majority of …
in a variety of organs A and species and under different dietary conditions. The majority of …
Comparison of different selenocompounds with respect to nutritional value vs. toxicity using liver cells in culture
CS Hoefig, K Renko, J Köhrle, M Birringer… - The Journal of nutritional …, 2011 - Elsevier
The essential micronutrient selenium (Se) exerts its biological effects mainly through
enzymatically active selenoproteins. Their biosynthesis depends on the 21st proteinogenic …
enzymatically active selenoproteins. Their biosynthesis depends on the 21st proteinogenic …
Selenium in the prevention and treatment of hepatocellular carcinoma
AS Darvesh, A Bishayee - Anti-Cancer Agents in Medicinal …, 2010 - ingentaconnect.com
Hepatocellular carcinoma (HCC) happens to be one of the most lethal cancers in the world.
Even though most cases occur in the developing world, reported cases in Western Europe …
Even though most cases occur in the developing world, reported cases in Western Europe …
Selenium as a cancer preventive agent
MI Jackson, GF Combs Jr - Selenium: its molecular biology and role in …, 2011 - Springer
The known metabolic functions of selenium, which appear to be discharged by a fairly small
number of selenoproteins, do not fully explain the anticarcinogenic effects of selenium …
number of selenoproteins, do not fully explain the anticarcinogenic effects of selenium …
The selenium metabolite selenodiglutathione induces cell death by a mechanism distinct from H2O2 toxicity
L Wu, J Lanfear, PR Harrison - Carcinogenesis, 1995 - academic.oup.com
Our previous studies have implicated the selenium metabolite selenodiglutathione (SDG) in
the growth inhibitory effects of selenite in vitro. Other work has suggested that reactive …
the growth inhibitory effects of selenite in vitro. Other work has suggested that reactive …
[HTML][HTML] Redox-active selenium compounds—From toxicity and cell death to cancer treatment
Selenium is generally known as an antioxidant due to its presence in selenoproteins as
selenocysteine, but it is also toxic. The toxic effects of selenium are, however, strictly …
selenocysteine, but it is also toxic. The toxic effects of selenium are, however, strictly …
Selenium: mechanistic aspects of anticarcinogenic action
GN Schrauzer - Biological trace element research, 1992 - Springer
Selenium is increasingly recognized as a versatile anticarcinogenic agent. Its protective
functions cannot be solely attributed to the action of glutathione peroxidase. Instead …
functions cannot be solely attributed to the action of glutathione peroxidase. Instead …