Differential sensitivity of various human tumour-derived cell types to apoptosis by organic derivatives of selenium

RJ Jariwalla, B Gangapurkar… - British journal of nutrition, 2008 - cambridge.org
Selenium is an important trace element with anti-cancer properties. In the present study, the
apoptosis-inducing effects of organic selenium derivatives, namely methyl-l-selenocysteine …

Novel strategies in selenium cancer chemoprevention research

C Ip, HE Ganther - Selenium in biology and human health, 1994 - Springer
Experimental studies with rodents indicate that selenium supplementation at levels above
the dietary requirement is capable of protecting against tumorigenesis induced by chemical …

Selenium and selenocysteine: roles in cancer, health, and development

DL Hatfield, PA Tsuji, BA Carlson… - Trends in biochemical …, 2014 - cell.com
The many biological and biomedical effects of selenium are relatively unknown outside the
selenium field. This fascinating element, initially described as a toxin, was subsequently …

Mechanisms of selenium inhibition of tumorigenesis

D Medina - Journal of the American College of Toxicology, 1986 - journals.sagepub.com
INTRODUCTION s IP HAS DISCUSSED,(') selenium supplementation inhibits tumorigenesis
in a variety of organs A and species and under different dietary conditions. The majority of …

Comparison of different selenocompounds with respect to nutritional value vs. toxicity using liver cells in culture

CS Hoefig, K Renko, J Köhrle, M Birringer… - The Journal of nutritional …, 2011 - Elsevier
The essential micronutrient selenium (Se) exerts its biological effects mainly through
enzymatically active selenoproteins. Their biosynthesis depends on the 21st proteinogenic …

Selenium in the prevention and treatment of hepatocellular carcinoma

AS Darvesh, A Bishayee - Anti-Cancer Agents in Medicinal …, 2010 - ingentaconnect.com
Hepatocellular carcinoma (HCC) happens to be one of the most lethal cancers in the world.
Even though most cases occur in the developing world, reported cases in Western Europe …

Selenium as a cancer preventive agent

MI Jackson, GF Combs Jr - Selenium: its molecular biology and role in …, 2011 - Springer
The known metabolic functions of selenium, which appear to be discharged by a fairly small
number of selenoproteins, do not fully explain the anticarcinogenic effects of selenium …

The selenium metabolite selenodiglutathione induces cell death by a mechanism distinct from H2O2 toxicity

L Wu, J Lanfear, PR Harrison - Carcinogenesis, 1995 - academic.oup.com
Our previous studies have implicated the selenium metabolite selenodiglutathione (SDG) in
the growth inhibitory effects of selenite in vitro. Other work has suggested that reactive …

[HTML][HTML] Redox-active selenium compounds—From toxicity and cell death to cancer treatment

S Misra, M Boylan, A Selvam, JE Spallholz… - Nutrients, 2015 - mdpi.com
Selenium is generally known as an antioxidant due to its presence in selenoproteins as
selenocysteine, but it is also toxic. The toxic effects of selenium are, however, strictly …

Selenium: mechanistic aspects of anticarcinogenic action

GN Schrauzer - Biological trace element research, 1992 - Springer
Selenium is increasingly recognized as a versatile anticarcinogenic agent. Its protective
functions cannot be solely attributed to the action of glutathione peroxidase. Instead …