Supplementation of selenium reduces chemical hepatocarcinogenesis in male Sprague-Dawley rats

N Alwahaibi, J Mohamed, A Alhamadani - Journal of Trace Elements in …, 2010 - Elsevier
Selenium is an essential micronutrient mineral found mainly in soils and has been shown to
prevent certain cancers in humans and animals. However, the dose and effects of selenium …

The two faces of selenium-can selenophobia be cured?

DV Frost, OE Olson - CRC critical reviews in toxicology, 1972 - Taylor & Francis
Selenium (Se), the most toxic but least plentiful of nutrients in the earth's crust, has two
distinct faces. It was named for Selene, the moon goddess. But Se, unlike the moon, shows …

Effects of organic and inorganic selenium compounds on rat mammary tumor cells

ZE Ronai, JK Tillotson, F Traganos… - … journal of cancer, 1995 - Wiley Online Library
To explore cellular effects of potent organoselenium chemo‐preventive agents we have
used a rat mammary tumor cell line. We demonstrate that 1, 4‐phenylenebis (methylene) …

Subacute toxicity of nano‐selenium compared to other selenium species in mice

I Benko, G Nagy, B Tanczos, E Ungvari… - Environmental …, 2012 - Wiley Online Library
Sixteen groups of mice were fed diets containing different selenium species to compare their
toxicity. Inorganic sodium selenate and sodium hydroselenite, elementary nanoSe, organic …

Chemopreventive and growth inhibitory effects of selenium.

PR Harrison, J Lanfear, L Wu, J Fleming… - Biomedical and …, 1997 - europepmc.org
There is very convincing evidence that a high dietary level of selenium substantially reduces
the incidence of a wide variety of animal cancers. The human epidemiological evidence is …

Negation of the cancer-preventive actions of selenium by over-expression of protein kinase Cε and selenoprotein thioredoxin reductase

U Gundimeda, JE Schiffman, SN Gottlieb… - …, 2009 - academic.oup.com
Selenium prevents cancer in some cases but fails to do so in others. Selenium's failure in
this respect may be due to the development of resistance to its chemopreventive actions …

Are selenoproteins important for the cancer protective effects of selenium?

CD Davis, R Irons - Current Nutrition & Food Science, 2005 - ingentaconnect.com
Epidemiologic and preclinical studies provide evidence that the essential nutrient selenium
has cancer protective properties. The mammalian genome encodes 25 selenoprotein genes …

The selenium metabolite selenodiglutathione induces p53 and apoptosis: relevance to the chemopreventive effects of selenium?

J Lanfear, J Fleming, L Wu, G Webster… - …, 1994 - academic.oup.com
Selenodiglutathione (SDG), the initial metabolite of selenite, is shown to be a more powerful
inhibitor of cell growth in vitro than selenite itself. This has been established both with mouse …

Molecular targets for selenium in cancer prevention

YS Kim, J Milner - Selenium and Cancer, 2001 - taylorfrancis.com
Mounting evidence reveals that selenium is a dietary constituent with anticarcinogenic and
antitumorigenic properties. Various forms of selenium appear to be effective in bringing …

Cancer chemoprevention: selenium as a prooxidant, not an antioxidant

EN Drake - Medical hypotheses, 2006 - Elsevier
Although the average daily dietary selenium (Se) intake in the United States is consistently
above the adult RDA of 55μg Se/day, supranutritional supplements of 200μg Se/day have …