We re-engineered the immunoglobulin rearrangements from clonally expanded CSF B cells
of three Multiple Sclerosis patients as Fab fragments, and used three methods to test for their …

Previous findings from our laboratory demonstrated that some clonally expanded
cerebrospinal fluid (CSF) B cells from MS patients exhibit diminished mutation targeting …

Purpose: to determine whether cerebrospinal fluid (CSF) B cells exhibit clonal expansion in
patients recently diagnosed with multiple sclerosis (MS). CSF B cell clonal expansion was …

Single-cell RT-PCR was used to sample CD19+ B cell repertoires in cerebrospinal fluid
(CSF) of patients with multiple sclerosis (MS) or viral meningitis. Analysis of amplified Ab H …

Clonally expanded populations of Ig variable gene-mutated B cells are found in the central
nervous system (CNS) of subjects with multiple sclerosis (MS), suggesting the occurrence of …

Introduction B cells are attracting increasing attention in the pathogenesis of multiple
sclerosis (MS). B cell-targeted therapies with monoclonal antibodies or plasmapheresis …

In multiple sclerosis (MS), lymphocyte—in particular B cell—transit between the central
nervous system (CNS) and periphery may contribute to the maintenance of active disease …

B cells isolated from the CSF of patients with multiple sclerosis (MS) have a unique
accumulation of somatic hypermutation, within the B cell receptor, termed the antibody gene …

Autoimmune B cells play a major role in mediating tissue damage in multiple sclerosis (MS).
In MS, B cells are believed to cross the blood-brain barrier and undergo stimulation, antigen …

The anti-CD20 antibody ocrelizumab, approved for treatment of multiple sclerosis, leads to
rapid elimination of B cells from the blood. The extent of B cell depletion and kinetics of their …