Following infection or vaccination, naïve CD8 T cells that receive the appropriate integration
of antigenic, co‐stimulatory and inflammatory signals undergo a programmed series of …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection of vaccinated
individuals is increasingly common but rarely results in severe disease, likely due to the …

The discovery of T cells resident in diverse tissues has altered our understanding of
adaptive immunity to encompass site-specific responses mediated by tissue-adapted …

Respiratory virus infections, such as those mediated by influenza virus, parainfluenza virus,
respiratory syncytial virus (RSV), severe acute respiratory syndrome coronavirus (SARS …

Recent studies have shown that tissue resident memory T cells (TRM) are critical to antiviral
host defense in peripheral tissues. This new appreciation of TRM that reside in epithelial …

Vaccination is the most effective means of preventing infectious diseases. Despite the
success of many vaccines, there is presently little knowledge of the immunological …

Memory T cell inflation is a process in which a large number of effector memory T cells
accumulates in peripheral tissues. This phenomenon is observed upon certain low level …

A fundamental benefit of immunological memory is the ability to respond in an enhanced
manner upon secondary encounter with the same pathogen. Tissue-resident memory CD8 T …

The long-term maintenance of memory T cells is essential for successful vaccines. Both the
quantity and the quality of the memory T-cell population must be maintained. The signals …

The induction of long‐lived populations of memory T cells residing in peripheral tissues is of
considerable interest for T cell‐based vaccines, as they can execute immediate effector …