Ischemic stroke (IS) is a fatal neurological disease that occurs when the blood flow to the
brain is disrupted, leading to brain tissue damage and functional impairment. Cellular …

Ischemic stroke is a well-recognized disease of aging, yet it is unclear how the age-
dependent vulnerability occurs and what are the underlying mechanisms. To address these …

Ischemic stroke is a detrimental neurological disease characterized by an irreversible infarct
core surrounded by an ischemic penumbra, a salvageable region of brain tissue. Unique …

Introduction Modification of the extracellular matrix (ECM) is one of the major processes in
the pathology of brain damage following an ischemic stroke. However, our understanding of …

Ischemic stroke (IS) is a detrimental neurological disease with limited treatments options. It
has been challenging to define the roles of brain cell subsets in IS onset and progression …

Stroke has been the leading cause of adult morbidity and mortality over the past several
years. After an ischemic stroke attack, many dormant or reversibly injured brain cells exist in …

Despite the obvious clinical significance of post-stroke angiogenesis in aged subjects, a
detailed transcriptomic analysis of post-stroke angiogenesis has not yet been undertaken in …

Senescence-associated alterations in microglia may have profound impact on cerebral
homeostasis and stroke outcomes. However, the lack of a transcriptome-wide comparison …

Recognizing age as a pivotal risk factor for age-associated diseases, particularly
neurodegenerative diseases (ND), such as Alzheimer's disease (AD)(Peng et al., 2021) and …

Age is a major common risk factor underlying neurodegenerative diseases, including
Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis. Previous …