Bioactive metabolites have wide-ranging biological activities and are a potential source of
future research and therapeutic tools. Here, we use nanovibrational stimulation to induce …

There is a pressing clinical need to develop cell-based bone therapies due to a lack of
viable, autologous bone grafts and a growing demand for bone grafts in musculoskeletal …

In regenerative medicine, techniques which control stem cell lineage commitment are a
rapidly expanding field of interest. Recently, nanoscale mechanical stimulation of …

Osteoporosis disrupts the fine-tuned balance between bone formation and resorption,
leading to reductions in bone quantity and quality and ultimately increasing fracture risk …

Bone grafts are one of the most commonly transplanted tissues. However, autologous grafts
are in short supply, and can be associated with pain and donor-site morbidity. The creation …

Stem cell fate can be directed through the application of various external physical stimuli,
enabling a controlled approach to targeted differentiation. Studies involving the use of …

Osteoporosis is a skeletal metabolic disease characterized by reduced bone mass and a
high susceptibility to fractures, in which osteoblasts and osteoclasts are highly involved in …

Bone marrow mesenchymal stem cells that are committed to adipogenesis were exposed
daily to high-frequency low-intensity mechanical vibrations to understand molecular …

Aim: Mesenchymal stem cells (MSCs) have large regenerative potential to replace damaged
cells from several tissues along the mesodermal lineage. The potency of these cells …

Biomechanical stimulation by whole-body low-magnitude high-frequency vibration (LMHFV)
has demonstrated to provoke anabolic effects on bone metabolism in both non-osteoporotic …