Whether chronic cannabinoid consumption produces a dependent state comparable to that
occurring with other drugs (eg the appearance of withdrawal signs when consumption is …

Although tolerance to cannabinoids has been well established, the question of cannabinoid
dependence had been very controversial until the discovery of a cannabinoid antagonist …

Rats were trained to lever press according to variable interval 10 s schedules during daily
experimental sessions composed of six 3 min food reinforcement periods and were treated …

Cannabinoid systems have been shown to be involved in the regulation of ingestive
behaviors. Administration of the cannabinoid antagonist, SR141716A, markedly reduces …

Precipitated withdrawal in rats chronically exposed to Δ9-tetrahydrocannabinol, the major
psychoactive principle of the marijuana plant, was unequivocally demonstrated for the first …

To characterize the time course of the behavioral and biochemical aspects of the
cannabinoid withdrawal syndrome, we injected the cannabinoid antagonist SR141716A (5 …

The central CB 1 cannabinoid receptor has recently been implicated in brain reward
function. In the present study we evaluated first the effects of the selective CB 1 receptor …

The availability of the cannabinoid antagonist, SR 141716A, to precipitate withdrawal
following repeated cannabinoid administration provides a model to investigate the …

Different animal models have been used to clarify the consequences of chronic exposure to
cannabinoid agonists and their abuse liability. Following the chronic administration of …

The effects of chronic Δ9-tetrahydrocannabinol on cannabinoid receptor levels and receptor–
G-protein coupling were investigated. Male Sprague–Dawley rats were infused continuously …