Simple Summary Treatment with ARSI results in an increased expression of the TLK1B
splice variant and consequent activation of the TLK1> NEK1> YAP axis. We now provide …

Simple Summary We earlier described the involvement of the TLK1> NEK1> ATR> Chk1
axis as a key determinant of cell cycle arrest in androgen-dependent prostate cancer (PCa) …

The key to preventing mCRPC progression is understanding how androgen-dependent PCa
cells progress to independence and modify their transcriptional repertoire accordingly. We …

Prostate cancer (PCa) progression is characterized by the emergence of resistance to
androgen deprivation therapy (ADT). AKT/PKB has been directly implicated in PCa …

Hippo signaling restricts tumor growth by inhibiting the oncogenic potential of YAP/TAZ‐
TEAD transcriptional complex. Here, we uncover a context‐dependent tumor suppressor …

The transcriptional co-activator Yes-associated protein 1 (YAP1), a key nuclear effector of
the Hippo pathway, is a potent oncogene, and yet, the interaction between YAP1 and …

Hippo signaling restricts tumor growth by inhibiting the oncogenic potential of YAP/TAZ-
TEAD transcriptional complex. Here we uncover a context-dependent tumor suppressor …

We recently uncovered the critical TLK1> NEK1> ATR> Chk1 axis in mediating the DDR and
cell cycle checkpoint while transiting from Androgen Sensitive to Insensitive growth for …

Despite recent efforts, prostate cancer (PCa) remains one of the most common cancers in
men. Currently, there is no effective treatment for castration-resistant prostate cancer …

Simple Summary Prostate cancer is the most commonly diagnosed cancer in men in the UK,
accounting for the deaths of over 11,000 men per year. A major problem in this disease are …