Rivastigmine-loaded PLGA and PBCA nanoparticles: preparation, optimization, characterization, in vitro and pharmacodynamic studies

SA Joshi, SS Chavhan, KK Sawant - European journal of pharmaceutics …, 2010 - Elsevier
Sustained release nanoparticulate formulations of Rivastigmine tartrate (RT) were prepared,
optimized (using factorial design) and characterized using the biodegradable polymers …

Optimization of brain targeted chitosan nanoparticles of Rivastigmine for improved efficacy and safety

K Nagpal, SK Singh, DN Mishra - International journal of biological …, 2013 - Elsevier
The study aims at formulation and optimization brain targeted nanoparticles (NP) of
Rivastigmine (RT) to improve its therapeutic potential and to verify its safety profile. The NP …

Development and evaluation of rivastigmine loaded chitosan nanoparticles for brain targeting

M Fazil, S Md, S Haque, M Kumar, S Baboota… - European Journal of …, 2012 - Elsevier
The rivastigmine (RHT) loaded chitosan nanoparticles (CS-RHT NPs) were prepared by
ionic gelation method to improve the bioavailability and enhance the uptake of RHT to the …

Estradiol loaded PLGA nanoparticles for oral administration: effect of polymer molecular weight and copolymer composition on release behavior in vitro and in vivo

G Mittal, DK Sahana, V Bhardwaj… - Journal of controlled …, 2007 - Elsevier
The present investigation was aimed at optimization of estradiol loaded PLGA
nanoparticulate formulations resulting in improved oral bioavailability and sustained release …

Poly (n-butylcyanoacrylate) nanoparticles coated with polysorbate 80 for the targeted delivery of rivastigmine into the brain to treat Alzheimer's disease

B Wilson, MK Samanta, K Santhi, KPS Kumar… - Brain research, 2008 - Elsevier
Alzheimer's disease is a progressive and fatal neurodegenerative disorder manifested by
cognitive and memory deterioration, progressive impairment of activities of daily living, and a …

Potential therapeutic effect of nanobased formulation of rivastigmine on rat model of Alzheimer's disease

MF Ismail, AN ElMeshad… - International journal of …, 2013 - Taylor & Francis
Background To sustain the effect of rivastigmine, a hydrophilic cholinesterase inhibitor,
nanobased formulations were prepared. The efficacy of the prepared rivastigmine liposomes …

PLGA nanoparticle formulations of risperidone: preparation and neuropharmacological evaluation

MS Muthu, MK Rawat, A Mishra, S Singh - … : Nanotechnology, Biology and …, 2009 - Elsevier
The aim of this work was to develop extended-release poly (d, l-lactide-co-glycolide)(PLGA)
nanoparticles of risperidone and thermal-responsive in situ gel containing risperidone …

Preparation, characterization, in vivo biodistribution and pharmacokinetic studies of donepezil-loaded PLGA nanoparticles for brain targeting

Bhavna, S Md, M Ali, S Baboota, JK Sahni… - Drug development …, 2014 - Taylor & Francis
Objective: Alzheimer's disease (AD) is a progressive neurodegenerative disorder
manifested by cognitive, memory deterioration and variety of neuropsychiatric symptoms …

Surface modified PLGA nanoparticles for brain targeting of Bacoside-A

S Jose, S Sowmya, TA Cinu, NA Aleykutty… - European Journal of …, 2014 - Elsevier
The present paper focuses on the development and in vitro/in vivo characterization of
nanoparticles composed of poly-(D, L)-Lactide-co-Glycolide (PLGA) loading Bacoside-A, as …

Boosted memory and improved brain bioavailability of rivastigmine: targeting effort to the brain using covalently tethered lower generation PAMAM dendrimers with …

A Gothwal, KT Nakhate, A Alexander… - Molecular …, 2018 - ACS Publications
Currently, there is no treatment strategy which can reverse the process of neuro-
degeneration in progression of Alzheimer's disease (AD). Practically, it is desired to achieve …