Mitochondrial nitric oxide synthase is constitutively active and is functionally upregulated in hypoxia
Z Lacza, M Puskar, JP Figueroa, J Zhang… - Free Radical Biology …, 2001 - Elsevier
Nitric oxide is a potent modulator of mitochondrial respiration, ATP synthesis, and KATP
channel activity. Recent studies show the presence of a potentionally new isoform of the …
channel activity. Recent studies show the presence of a potentionally new isoform of the …
[HTML][HTML] Biochemistry of mitochondrial nitric-oxide synthase
SL Elfering, TM Sarkela, C Giulivi - Journal of Biological Chemistry, 2002 - ASBMB
We reported that the generation of nitric oxide by mitochondria is catalyzed by a constitutive,
mitochondrial nitric-oxide synthase (mtNOS). Given that this production may establish the …
mitochondrial nitric-oxide synthase (mtNOS). Given that this production may establish the …
Mitochondrial nitric oxide synthase is not eNOS, nNOS or iNOS
Z Lacza, JA Snipes, J Zhang, EM Horváth… - Free Radical Biology …, 2003 - Elsevier
Recent studies indicated that there is a distinct mitochondrial nitric oxide synthase (mtNOS)
enzyme, which may be identical to the other known NOS isoforms. We investigated the …
enzyme, which may be identical to the other known NOS isoforms. We investigated the …
Mitochondrial nitric‐oxide synthase: role in pathophysiology
V Haynes, S Elfering, R Squires, N Traaseth… - IUBMB …, 2003 - Wiley Online Library
The biochemistry of the mitochondrial production of nitric oxide is reviewed to gain insight
into the basic role of this radical in mitochondrial and cellular oxidative metabolism. The …
into the basic role of this radical in mitochondrial and cellular oxidative metabolism. The …
Mitochondrial nitric-oxide synthase: enzyme expression, characterization, and regulation
V Haynes, S Elfering, N Traaseth, C Giulivi - Journal of bioenergetics and …, 2004 - Springer
Nitric oxide is generated in vivo by nitric-oxide synthase (NOS) during the conversion of L-
Arg to citrulline. Using a variety of biological systems and approaches emerging evidence …
Arg to citrulline. Using a variety of biological systems and approaches emerging evidence …
[HTML][HTML] The modulation of mitochondrial nitric-oxide synthase activity in rat brain development
NA Riobó, M Melani, N Sanjuán, ML Fiszman… - Journal of Biological …, 2002 - ASBMB
Different mitochondrial nitric-oxide synthase (mtNOS) isoforms have been described in rat
and mouse tissues, such as liver, thymus, skeletal muscle, and more recently, heart and …
and mouse tissues, such as liver, thymus, skeletal muscle, and more recently, heart and …
Neuronal nitric oxide synthase controls enzyme activity pattern of mitochondria and lipid metabolism
L Schild, I Jaroscakova, U Lendeckel, G Wolf… - The FASEB …, 2006 - Wiley Online Library
Mitochondria are affected by endogenous nitric oxide (NO). Besides effects of NO on
mitochondrial enzymes and the stimulation of mitochondrial H2O2 production, a NO …
mitochondrial enzymes and the stimulation of mitochondrial H2O2 production, a NO …
Oxygen dependence of mitochondrial nitric oxide synthase activity
S Alvarez, LB Valdez, T Zaobornyj, A Boveris - … and biophysical research …, 2003 - Elsevier
The effect of O2 concentration on mitochondrial nitric oxide synthase (mtNOS) activity and
on O2− production was determined in rat liver, brain, and kidney submitochondrial …
on O2− production was determined in rat liver, brain, and kidney submitochondrial …
Heart mitochondrial nitric oxide synthase. Effects of hypoxia and aging
LB Valdez, T Zaobornyj, S Alvarez… - Molecular aspects of …, 2004 - Elsevier
The production of NO by heart mitochondria was 0.7–1.1 nmol NO/min. mg protein, an
activity similar to the ones observed in mitochondrial membranes from other organs. Heart …
activity similar to the ones observed in mitochondrial membranes from other organs. Heart …
Brain mitochondrial nitric oxide synthase: in vitro and in vivo inhibition by chlorpromazine
S Lores-Arnaiz, G D'Amico, A Czerniczyniec… - Archives of biochemistry …, 2004 - Elsevier
Mouse brain mitochondria have a nitric oxide synthase (mtNOS) of 147kDa that reacts with
anti-nNOS antibodies and that shows an enzymatic activity of 0.31–0.48 nmol NO/minmg …
anti-nNOS antibodies and that shows an enzymatic activity of 0.31–0.48 nmol NO/minmg …