Nitric oxide is a potent modulator of mitochondrial respiration, ATP synthesis, and KATP
channel activity. Recent studies show the presence of a potentionally new isoform of the …

We reported that the generation of nitric oxide by mitochondria is catalyzed by a constitutive,
mitochondrial nitric-oxide synthase (mtNOS). Given that this production may establish the …

Recent studies indicated that there is a distinct mitochondrial nitric oxide synthase (mtNOS)
enzyme, which may be identical to the other known NOS isoforms. We investigated the …

The biochemistry of the mitochondrial production of nitric oxide is reviewed to gain insight
into the basic role of this radical in mitochondrial and cellular oxidative metabolism. The …

Nitric oxide is generated in vivo by nitric-oxide synthase (NOS) during the conversion of L-
Arg to citrulline. Using a variety of biological systems and approaches emerging evidence …

Different mitochondrial nitric-oxide synthase (mtNOS) isoforms have been described in rat
and mouse tissues, such as liver, thymus, skeletal muscle, and more recently, heart and …

Mitochondria are affected by endogenous nitric oxide (NO). Besides effects of NO on
mitochondrial enzymes and the stimulation of mitochondrial H2O2 production, a NO …

The effect of O2 concentration on mitochondrial nitric oxide synthase (mtNOS) activity and
on O2− production was determined in rat liver, brain, and kidney submitochondrial …

The production of NO by heart mitochondria was 0.7–1.1 nmol NO/min. mg protein, an
activity similar to the ones observed in mitochondrial membranes from other organs. Heart …

Mouse brain mitochondria have a nitric oxide synthase (mtNOS) of 147kDa that reacts with
anti-nNOS antibodies and that shows an enzymatic activity of 0.31–0.48 nmol NO/minmg …