Recent advances strongly suggest that mRNA rather than DNA will be the nucleotide basis
for a new class of vaccines and drugs. Therapeutic cancer vaccines against a variety of …

Highlights•mRNA vaccines continue to show promise as prophylactic and therapeutic
vaccines.•Clinical data with mRNA cancer vaccines indicate they are tolerated and …

mRNA is the central molecule of all forms of life. It is generally accepted that current life on
Earth descended from an RNA world. mRNA, after its first therapeutic description in 1992 …

Abstract mRNA-based drugs have tremendous potential as clinical treatments, however, a
major challenge in realizing this drug class will promise to develop methods for safely …

Highlights•mRNA is a key component of mRNA vaccine as the biological blueprint encoding
for proteins.•mRNA strategies comprise preventive vaccinations for therapeutic vaccines …

Highlights•mRNA vaccines address many of the weaknesses of conventional vaccine
types.•Innovations in recent years revolutionized the applicability of mRNA vaccines.•mRNA …

Abstract mRNA vaccines represent a promising alternative to conventional vaccine
approaches because of their high potency, capacity for rapid development and potential for …

The mRNA-based vaccine approach is a promising alternative to traditional vaccines due to
its ability for prompt development, high potency, and potential for secure administration and …

The first proof-of-concept studies about the feasibility of genetic vaccines were published
over three decades ago, opening the way for future development. The idea of nonviral …

During the last decade, mRNA became increasingly recognized as a versatile tool for the
development of new innovative therapeutics. Especially for vaccine development, mRNA is …