CGRP receptor signalling pathways

GS Cottrell - Calcitonin gene-related peptide (CGRP) mechanisms …, 2019 - Springer
Calcitonin gene-related peptide (CGRP) is a promiscuous peptide, similar to many other
members of the calcitonin family of peptides. The potential of CGRP to act on many different …

Regulation of signal transduction by calcitonin gene-related peptide receptors

CS Walker, AC Conner, DR Poyner, DL Hay - Trends in pharmacological …, 2010 - cell.com
Calcitonin gene-related peptide (CGRP) plays a pivotal role in migraine, activating its
cognate receptor to initiate intracellular signalling. This atypical receptor comprises a distinct …

CGRP physiology, pharmacology, and therapeutic targets: migraine and beyond

AF Russo, DL Hay - Physiological reviews, 2023 - journals.physiology.org
Calcitonin gene-related peptide (CGRP) is a neuropeptide with diverse physiological
functions. Its two isoforms (α and β) are widely expressed throughout the body in sensory …

CGRP receptor antagonism and migraine therapy

L Edvinsson, K Warfvinge - Current Protein and Peptide …, 2013 - ingentaconnect.com
Migraine is the most prevalent of the neurological disorders and can affect the patient
throughout the lifetime. Calcitonin gene-related peptide (CGRP) is a neuropeptide that is …

CGRP in animal models of migraine

AS Wattiez, M Wang, AF Russo - Calcitonin Gene-Related Peptide (CGRP …, 2019 - Springer
With the approval of calcitonin gene-related peptide (CGRP) and CGRP receptor
monoclonal antibodies by the Federal Drug Administration, a new era in the treatment of …

Calcitonin gene-related peptide (CGRP): role in migraine pathophysiology and therapeutic targeting

AS Wattiez, LP Sowers, AF Russo - Expert opinion on therapeutic …, 2020 - Taylor & Francis
Introduction: The neuropeptide calcitonin gene-related peptide (CGRP) is recognized as a
critical player in migraine pathophysiology. Excitement has grown regarding CGRP because …

CGRP receptor biology: is there more than one receptor?

DL Hay - Calcitonin Gene-Related Peptide (CGRP) Mechanisms …, 2019 - Springer
Calcitonin gene-related peptide (CGRP) has many reported pharmacological actions. Can a
single receptor explain all of these? This chapter outlines the molecular nature of reported …

Calcitonin gene-related peptide (CGRP): a new target for migraine

AF Russo - Annual review of pharmacology and toxicology, 2015 - annualreviews.org
Migraine is a neurological disorder that manifests as a debilitating headache associated
with altered sensory perception. The neuropeptide calcitonin gene-related peptide (CGRP) …

Calcitonin gene-related peptide in migraine: intersection of peripheral inflammation and central modulation

AC Raddant, AF Russo - Expert reviews in molecular medicine, 2011 - cambridge.org
Over the past two decades, a convergence of basic and clinical evidence has established
the neuropeptide calcitonin-gene-related peptide (CGRP) as a key player in migraine …

Differential distribution of calcitonin gene-related peptide and its receptor components in the human trigeminal ganglion

S Eftekhari, CA Salvatore, A Calamari, SA Kane, J Tajti… - Neuroscience, 2010 - Elsevier
Calcitonin gene related peptide (CGRP) has a key role in migraine and recently CGRP
receptor antagonists have demonstrated clinical efficacy in the treatment of migraine …