ACE2, a new regulator of the renin–angiotensin system

LM Burrell, CI Johnston, C Tikellis… - Trends in Endocrinology & …, 2004 - cell.com
Angiotensin-converting enzyme (ACE) is a zinc metalloproteinase and a key regulator of the
renin–angiotensin system (RAS). ACE2 is a newly described enzyme identified in rodents …

Angiotensin-converting enzyme II in the heart and the kidney

U Danilczyk, JM Penninger - Circulation research, 2006 - Am Heart Assoc
The renin-angiotensin system (RAS) has been recognized for many years as critical
pathway for blood pressure control and kidney functions. Although most of the well-known …

The role of ACE2 in cardiovascular physiology

GY Oudit, MA Crackower, PH Backx… - Trends in cardiovascular …, 2003 - Elsevier
The renin–angiotensin system (RAS) is critically involved in cardiovascular and renal
function and in disease conditions, and has been shown to be a far more complex system …

Advances in biochemical and functional roles of angiotensin-converting enzyme 2 and angiotensin-(1–7) in regulation of cardiovascular function

CM Ferrario, AJ Trask… - American Journal of …, 2005 - journals.physiology.org
Angiotensin-converting enzyme 2 (ACE2) is the first human homologue of ACE to be
described. ACE2 is a type I integral membrane protein that functions as a carboxypeptidase …

Characterization of renal angiotensin-converting enzyme 2 in diabetic nephropathy

C Tikellis, CI Johnston, JM Forbes, WC Burns… - …, 2003 - Am Heart Assoc
ACE2, initially cloned from a human heart, is a recently described homologue of angiotensin-
converting enzyme (ACE) but contains only a single enzymatic site that catalyzes the …

Angiotensin-converting enzyme 2 and new insights into the renin–angiotensin system

DW Lambert, NM Hooper, AJ Turner - Biochemical pharmacology, 2008 - Elsevier
Components of the renin–angiotensin system are well established targets for
pharmacological intervention in a variety of disorders. Many such therapies abrogate the …

Angiotensin‐converting enzyme 2: the first decade

NE Clarke, AJ Turner - International journal of hypertension, 2012 - Wiley Online Library
The renin‐angiotensin system (RAS) is a critical regulator of hypertension, primarily through
the actions of the vasoactive peptide Ang II, which is generated by the action of angiotensin …

Angiotensin‐converting enzyme 2 (ACE2) is a key modulator of the renin angiotensin system in health and disease

C Tikellis, MC Thomas - International journal of peptides, 2012 - Wiley Online Library
Angiotensin‐converting enzyme 2 (ACE2) shares some homology with angiotensin‐
converting enzyme (ACE) but is not inhibited by ACE inhibitors. The main role of ACE2 is the …

[HTML][HTML] ACE2 cell biology, regulation, and physiological functions

AJ Turner - The protective arm of the renin angiotensin system …, 2015 - ncbi.nlm.nih.gov
Abstract Angiotensin-converting enzyme 2 (ACE2), discovered as a homologue of ACE, acts
as its physiological counterbalance providing homeostatic regulation of circulating …

Angiotensin-converting enzyme 2: implications for blood pressure and kidney disease

JR Ingelfinger - Current opinion in nephrology and hypertension, 2009 - journals.lww.com
Angiotensin-converting enzyme 2: implications for blood pres... : Current Opinion in Nephrology
and Hypertension Angiotensin-converting enzyme 2: implications for blood pressure and kidney …