The p38 mitogen-activated protein (MAP) kinase signal transduction pathway is activated by
proinflammatory cytokines and environmental stress. The detection of p38 MAP kinase in the …

The p38 mitogen-activated protein kinase (MAPK) is activated in vitro by three different
protein kinases: MKK3, MKK4, and MKK6. To examine the relative roles of these protein …

The cellular response to treatment with proinflammatory cytokines or exposure to
environmental stress is mediated, in part, by the p38 group of mitogen-activated protein …

The p38 mitogen-activated protein kinase is activated by treatment of cells with cytokines
and by exposure to environmental stress. The effects of these stimuli on p38 MAP kinase are …

Mitogen-activated protein (MAP) kinase cascades represent one of the major signal systems
used by eukaryotic cells to transduce extracellular signals into cellular responses. Four MAP …

All four members of the mammalian p38 mitogen-activated protein kinase (MAPK) family
(p38α, p38β, p38γ and p38δ) are activated by dual phosphorylation in the TGY motif in the …

Protein kinases activated by dual phosphorylation on Tyr and Thr (MAP kinases) can be
grouped into two major classes: ERK and JNK. The ERK group regulates multiple targets in …

The stress-activated protein kinase p38 stabilizes a number of mRNAs encoding
inflammatory mediators, such as cyclooxygenase 2 (Cox-2). In HeLa cells the anti …

Mitogen-activated protein kinases (MAPK) are activated by phosphorylation on Thr and Tyr
by MAPK kinases. Two MAPK kinases (MKK4 and MKK7) can activate the c-Jun NH2 …

p38 mitogen-activated protein kinases (MAPKs) are activated primarily in response to
inflammatory cytokines and cellular stress, and inhibitors which target the p38α and p38β …