At least 19 loci harbor common variations that contribute to blood lipid concentrations in
humans. Larger scale genome-wide association studies should identify additional loci, and …

Genetic studies have identified many loci associated with plasma lipids and have provided
insight into the underlying mechanisms of lipid homeostasis. Future research is needed to …

Serum concentrations of low-density lipoprotein cholesterol (LDL-C), high-density
lipoprotein cholesterol (HDL-C), triglycerides (TGs) and total cholesterol (TC) are important …

Current results have increased our understanding of the genetic architecture of lipids,
expanding the range of effect and frequency for variants identified for lipid traits …

Deep sequencing of genome-wide association signals promises to expand the catalogue of
variants responsible for serum lipid variation and, with a full catalogue of variants, we may …

Background Whereas it is well established that plasma lipid levels have substantial
heritability within populations, it remains unclear how many of the genetic determinants …

Levels of low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL)
cholesterol, triglycerides and total cholesterol are heritable, modifiable risk factors for …

Genome-wide association studies (GWASs) have identified many SNPs underlying
variations in plasma-lipid levels. We explore whether additional loci associated with plasma …

Lipid levels are important markers for the development of cardio-metabolic diseases.
Although hundreds of associated loci have been identified through genetic association …

Blood lipid concentrations are heritable risk factors associated with atherosclerosis and
cardiovascular diseases. Lipid traits exhibit considerable variation among populations of …