Understanding genetic architecture of plasma lipidome could provide better insights into
lipid metabolism and its link to cardiovascular diseases (CVDs). Here, we perform genome …

The genetic dissection of complex inherited diseases is a major challenge. Despite limited
success in finding genes, substantial data based on genome-wide scan strategies is now …

A wealth of novel lipid loci have been identified through a variety of approaches focused on
common and low-frequency variation and collaborative metaanalyses in multiethnic …

Plasma lipid levels are risk factors for cardiovascular disease, a leading cause of death
worldwide. While many studies have been conducted in genetic variation underlying lipid …

Recent genome-wide association studies have identified multiple loci robustly associated
with plasma lipids, which also contribute to extreme lipid phenotypes. However, these …

Large-scale gene sequencing studies for complex traits have the potential to identify causal
genes with therapeutic implications. We performed gene-based association testing of blood …

Lipid concentrations are heritable traits. Recently, the number of known genetic loci
associated with lipid levels in adults increased from 95 to 157. The effects of these 157 loci …

Plasma lipoprotein concentrations are associated with risk of coronary artery disease, a
leading cause of mortality and morbidity worldwide. Three new genome-wide association …

Increased blood lipid levels are heritable risk factors of cardiovascular disease with varied
prevalence worldwide owing to different dietary patterns and medication use. Despite …

Background A recent, large genome-wide association study (GWAS) of European ancestry
individuals has identified multiple genetic variants influencing serum lipids. Studies of the …