Single nucleotide polymorphisms (SNPs) and derived haplotypes within multiple genes may
explain genetic variance in complex traits; however, this hypothesis has not been rigorously …

It has been hypothesized that low frequency (1–5% minor allele frequency (MAF)) and rare
(< 1% MAF) variants with large effect sizes may contribute to the missing heritability in …

Cardiovascular disease is the leading cause of morbidity and mortality in the developed
world. Epidemiologic data support a strong relationship of atherosclerotic cardiovascular …

Background The identification of genetic variants related to blood lipid levels within a large,
population-based and nationally representative study might lead to a better understanding …

Background—Recent genome-wide association studies have found 95 distinct genetic loci
associated with high-density (HDL-C) and low-density (LDL-C) lipoprotein cholesterol, total …

Genome-wide association studies (GWAS) have identified multiple loci associated with
plasma lipid concentrations,,,,. Common variants at these loci together explain< 10% of …

Dyslipidemia is strongly associated with raised plasma glucose levels and insulin resistance
(IR), and genome-wide association studies have identified 95 loci that explain a substantial …

Clinical lipid measurements have been the mainstay of risk assessment for chronic disease
since the Framingham study commenced over 60 years ago. Thousands of subsequent …

Background Circulating lipids levels, as well as several familial lipid metabolism disorders,
are strongly associated with initiation and progression of atherosclerosis and incidence of …

Susceptibility to the growing global public health problem of cardiovascular disease is
associated with levels of plasma lipids and lipoproteins. Several experimental strategies …