Rearrangement of the RET gene, also known as RET/PTC rearrangement, is the most
common genetic alteration identified to date in thyroid papillary carcinomas. The prevalence …

The RET proto-oncogene encodes a cell membrane tyrosine-kinase receptor protein whose
ligands belong to the glial cell line–derived neurotrophic factor. RET functions as a …

Context: RET/PTC rearrangements have been reported in papillary thyroid carcinomas with
variable frequency in studies that used different detection methods. Objective: Our objective …

Thyroid carcinoma is the most frequent endocrine cancer accounting for 5–10% of thyroid
nodules. Papillary histotype (PTC) is the most prevalent form accounting for 80% of all …

Rearrangements involving the RET protooncogene have been implicated in the
development of papillary thyroid carcinoma (PC). Transgenic mice, expressing thyroid …

The ret/PTC rearrangements (PTC-1, PTC-2, and PTC-3) are characteristic of papillary
thyroid cancer (PTC). In adults, PTC-1 is common and may be associated with an …

The ret/PTC oncogene is unique to papillary thyroid cancer. Three forms of this oncogene,
formed by translocation of three different genes to the tyrosine kinase domain of the ret …

Malignant tumors of the thyroid gland vary considerably in aggressiveness, ranging from a
well-differentiated, clinically indolent, to an undifferentiated, often lethal phenotype …

Hyalinizing trabecular tumor (HTT) of the thyroid is a neoplasm of follicular derivation with a
histogenesis that is still the subject of debate. Morphologic affinities between HTT and …

Rearrangements of the RET proto-oncogene may occur in both naturally occurring and
radiation-induced papillary thyroid carcinomas. Conflicting results on the frequency and type …