Whole-genome landscape of adult T-cell leukemia/lymphoma

Y Kogure, T Kameda, J Koya… - Blood, The Journal …, 2022 - ashpublications.org
Adult T-cell leukemia/lymphoma (ATL) is an aggressive neoplasm immunophenotypically
resembling regulatory T cells, associated with human T-cell leukemia virus type-1. Here, we …

Integrated molecular analysis of adult T cell leukemia/lymphoma

K Kataoka, Y Nagata, A Kitanaka, Y Shiraishi… - Nature …, 2015 - nature.com
Adult T cell leukemia/lymphoma (ATL) is a peripheral T cell neoplasm of largely unknown
genetic basis, associated with human T cell leukemia virus type-1 (HTLV-1) infection. Here …

Targeted deep sequencing reveals clonal and subclonal mutational signatures in Adult T-cell leukemia/lymphoma and defines an unfavorable indolent subtype

A Marçais, L Lhermitte, M Artesi, C Laurent, K Durkin… - Leukemia, 2021 - nature.com
Adult T-cell leukemia/lymphoma (ATL) carries a poor prognosis even in indolent subtypes.
We performed targeted deep sequencing combined with mapping of HTLV-1 proviral …

Chronological genome and single-cell transcriptome integration characterizes the evolutionary process of adult T cell leukemia-lymphoma

M Yamagishi, M Kubokawa, Y Kuze, A Suzuki… - Nature …, 2021 - nature.com
Subclonal genetic heterogeneity and their diverse gene expression impose serious
problems in understanding the behavior of cancers and contemplating therapeutic …

Prognostic relevance of integrated genetic profiling in adult T-cell leukemia/lymphoma

K Kataoka, M Iwanaga, J Yasunaga… - Blood, The Journal …, 2018 - ashpublications.org
Adult T-cell leukemia/lymphoma (ATL) is a heterogeneous group of peripheral T-cell
malignancies characterized by human T-cell leukemia virus type-1 infection, whose genetic …

Adult T-cell leukemia: molecular basis for clonal expansion and transformation of HTLV-1–infected T cells

T Watanabe - Blood, The Journal of the American Society of …, 2017 - ashpublications.org
Adult T-cell leukemia (ATL) is an aggressive T-cell malignancy caused by human T-cell
leukemia virus type 1 (HTLV-1) that develops through a multistep carcinogenesis process …

Identification of subtype-specific genomic alterations in aggressive adult T-cell leukemia/lymphoma

A Oshiro, H Tagawa, K Ohshima, K Karube, N Uike… - Blood, 2006 - ashpublications.org
Aggressive adult T-cell leukemia/lymphoma (ATLL) such as acute and lymphoma types are
fatal diseases with poor prognosis. Although these 2 subtypes feature different …

RNA sequencing identifies clonal structure of T-cell repertoires in patients with adult T-cell leukemia/lymphoma

A Farmanbar, R Kneller, S Firouzi - NPJ genomic medicine, 2019 - nature.com
The diversity of T-cell receptor (TCR) repertoires, as generated by somatic DNA
rearrangements, is central to immune system function. High-throughput sequencing …

Genetic alterations in adult T‐cell leukemia/lymphoma

Y Kogure, K Kataoka - Cancer science, 2017 - Wiley Online Library
Adult T‐cell leukemia/lymphoma (ATL) is a peripheral T‐cell neoplasm with a dismal
prognosis. It is caused by human T‐cell leukemia virus type‐1 (HTLV‐1) retrovirus. A long …

North American ATLL has a distinct mutational and transcriptional profile and responds to epigenetic therapies

UA Shah, EY Chung, O Giricz… - Blood, The Journal …, 2018 - ashpublications.org
Adult T-cell leukemia lymphoma (ATLL) is a rare T cell neoplasm that is endemic in
Japanese, Caribbean, and Latin American populations. Most North American ATLL patients …