Background To improve cancer therapy, it is critical to target metastasizing cells. Circulating
tumor cells (CTCs) are rare cells found in the blood of patients with solid tumors and may …

Tumor cells detach from the primary tumor or metastatic sites and enter the peripheral blood,
often causing metastasis. These cells, named Circulating Tumor Cells (CTCs), display the …

Molecular characterization of circulating tumor cells (CTC) from blood is technically
challenging because cells are rare and difficult to isolate. We developed a novel approach …

Increasing evidence suggests that cancer cells display dynamic molecular changes in
response to systemic therapy. Circulating tumor cells (CTCs) in the peripheral blood …

BACKGROUND Circulating tumor cells (CTCs) are promising surrogate markers for systemic
disease, and their molecular characterization might be relevant to guide more individualized …

Circulating tumor cells (CTCs) are established cancer biomarkers for the “liquid biopsy” of
tumors. Molecular analysis of single CTCs, which recapitulate primary and metastatic tumor …

Metastases from primary tumors are responsible for most cancer deaths. It has been shown
that circulating tumor cells (CTCs) can be detected in the peripheral blood of patients with a …

Circulating tumor cells (CTCs) shed from primary and metastatic cancers are admixed with
blood components and are thus rare, making their isolation and characterization a major …

The mutational and phenotypic landscape of tumors is dynamic, requiring constant
monitoring of cancer patients to provide the most up-to-date and effective care. Circulating …

Early dissemination, blood circulation, or homing of single tumor cells in bone marrow and
other organs is usually undetectable at primary diagnosis, even by high resolution imaging …