Tocilizumab in COVID-19: a meta-analysis, trial sequential analysis, and meta-regression of randomized-controlled trials

TAC Snow, N Saleem, G Ambler, E Nastouli… - Intensive Care …, 2021 - Springer
Abstract Purpose Interleukin-6 (IL-6) levels discriminate between patients with mild and
severe COVID-19, making IL-6 inhibition an attractive therapeutic strategy. We conducted a …

Efficacy and safety of tocilizumab in severe and critical COVID-19: a systematic review and meta-analysis

S Rezaei, B Fatemi, Z Karimi Majd… - Expert review of …, 2021 - Taylor & Francis
Objectives Currently published papers and clinical guidelines regarding the effects of
tocilizumab in severe and critical COVID-19 are contradictory. The aim of this meta-analysis …

[HTML][HTML] Efficacy and safety of tocilizumab in COVID-19 patients: a living systematic review and meta-analysis

IM Tleyjeh, Z Kashour, M Damlaj, M Riaz… - Clinical Microbiology …, 2021 - Elsevier
Objectives Cytokine release syndrome with elevated interleukin-6 (IL-6) levels is associated
with multiorgan damage and death in severe coronavirus disease 2019 (COVID-19). Our …

Tocilizumab in hospitalized patients with COVID-19: a meta analysis of randomized controlled trials

V Selvaraj, MS Khan, C Bavishi, K Dapaah-Afriyie… - Lung, 2021 - Springer
Background To date, only dexamethasone has been shown to reduce mortality in
coronavirus disease-19 (COVID-19) patients. Tocilizumab has been recently added to the …

[HTML][HTML] Efficacy and safety of tocilizumab in COVID-19 patients: a living systematic review and meta-analysis, first update

IM Tleyjeh, Z Kashour, M Riaz, L Hassett… - Clinical Microbiology …, 2021 - Elsevier
Objectives Cytokine release syndrome with elevated interleukin-6 (IL-6) levels is associated
with multiorgan damage and death in severe coronavirus disease 2019 (COVID-19). Our …

Tocilizumab treatment for COVID-19 patients: a systematic review and meta-analysis

Q Wei, H Lin, RG Wei, N Chen, F He, DH Zou… - Infectious diseases of …, 2021 - Springer
Abstract Background Coronavirus disease 2019 (COVID-19) has killed over 2.5 million
people worldwide, but effective care and therapy have yet to be discovered. We conducted …

Tocilizumab administration for the treatment of hospitalized patients with COVID‐19: a systematic review and meta‐analysis

C Kyriakopoulos, G Ntritsos, A Gogali, H Milionis… - …, 2021 - Wiley Online Library
Tocilizumab has been repurposed against the 'cytokine storm'in the setting of coronavirus
disease 2019 (COVID‐19). Our aim was to evaluate the efficacy of tocilizumab in the …

Tocilizumab in patients hospitalized with Covid-19 pneumonia

C Salama, J Han, L Yau, WG Reiss… - … England Journal of …, 2021 - Mass Medical Soc
Abstract Background Coronavirus disease 2019 (Covid-19) pneumonia is often associated
with hyperinflammation. Despite the disproportionate incidence of Covid-19 among …

Outcomes in patients with severe COVID-19 disease treated with tocilizumab: a case–controlled study

G Rojas-Marte, M Khalid, O Mukhtar… - … Journal of Medicine, 2020 - academic.oup.com
Background COVID-19 is an ongoing threat to society. Patients who develop the most
severe forms of the disease have high mortality. The interleukin-6 inhibitor tocilizumab has …

Efficacy and safety of tocilizumab for coronavirus disease 2019 (Covid-19) patients: a systematic review and meta-analysis

TI Hariyanto, W Hardyson, A Kurniawan - Drug research, 2021 - thieme-connect.com
Background Currently, the data regarding the effectiveness and safety of tocilizumab as
treatment for COVID-19 infection is still conflicting. This study aims to give clear evidence …