Background Vertebral endplate signal intensity changes visualized by magnetic resonance
imaging termed Modic changes (MC) are highly prevalent in low back pain patients …

Purpose Low back pain (LBP) is the most disabling condition worldwide. Although LBP
relates to different spinal pathologies, vertebral bone marrow lesions visualized as Modic …

Background No previous clinical trials have investigated MRI findings as effect modifiers for
conservative treatment of low back pain. This hypothesis-setting study investigated if MRI …

Purpose To analyse the presence of endplate sclerosis in patients with various types of
Modic changes (MCs) and to confirm the results using a rabbit model. Methods Participants …

Study Design. A prospective study was conducted to investigate the outcome of the Modic
Type 1 inflammatory signal in magnetic resonance imaging (MRI) in 17 patients with chronic …

Background To summarize the clinical distribution of Modic changes in patients with low
back pain and explore the related factors. Methods A total of 153 patients were enrolled …

Study Design. Large-scale, prospective, population-based, longitudinal observational study.
Objective. The aim of this study was to investigate the rate of incidence, transformation, and …

Background Modic 1 changes are usually associated with degenerative disc disease (DDD).
We aimed to compare Modic 1 changes with advanced degenerative disc disease (> 50 …

Purpose In the literature, inter-vertebral MRI signal intensity changes (Modic changes) were
associated with corresponding histological observations on endplate biopsies. However …

Background Blocking the lumbar or lumbosacral spine with a custom-made rigid lumbar
brace, based on the mechanical origin of active discopathy, is a therapeutic option for low …