Designing injectable, covalently cross‐linked hydrogels for biomedical applications

M Patenaude, NMB Smeets… - Macromolecular rapid …, 2014 - Wiley Online Library
Hydrogels that can form spontaneously via covalent bond formation upon injection in vivo
have recently attracted significant attention for their potential to address a variety of …

In situ gelling hydrogels for pharmaceutical and biomedical applications

SR Van Tomme, G Storm, WE Hennink - International journal of …, 2008 - Elsevier
Since Wichterle et al. introduced hydrogels as novel materials possibly suitable for a variety
of biomedical applications, hydrogel research has become a fast-developing and exciting …

Hydrogels in a historical perspective: From simple networks to smart materials

SJ Buwalda, KWM Boere, PJ Dijkstra, J Feijen… - Journal of controlled …, 2014 - Elsevier
Over the past decades, significant progress has been made in the field of hydrogels as
functional biomaterials. Biomedical application of hydrogels was initially hindered by the …

Tuning gelation time and morphology of injectable hydrogels using ketone–hydrazide cross-linking

M Patenaude, S Campbell, D Kinio, T Hoare - Biomacromolecules, 2014 - ACS Publications
Injectable, covalently in situ forming hydrogels based on poly (N-isopropylacrylamide) have
been designed on the basis of mixing hydrazide-functionalized nucleophilic precursor …

Covalently Crosslinked hydrogels via step‐growth reactions: crosslinking chemistries, polymers, and clinical impact

Y Gao, K Peng, S Mitragotri - Advanced Materials, 2021 - Wiley Online Library
Hydrogels are an important class of biomaterials with the unique property of high‐water
content in a crosslinked polymer network. In particular, chemically crosslinked hydrogels …

Injectable polymeric hydrogels for the delivery of therapeutic agents: A review

QV Nguyen, JH Park, DS Lee - European Polymer Journal, 2015 - Elsevier
Since drug delivery systems have become one of the most promising areas of human health
related research, the applications of biomaterials such as hydrogels have been widely …

Translational applications of hydrogels

S Correa, AK Grosskopf, H Lopez Hernandez… - Chemical …, 2021 - ACS Publications
Advances in hydrogel technology have unlocked unique and valuable capabilities that are
being applied to a diverse set of translational applications. Hydrogels perform functions …

Weak bond-based injectable and stimuli responsive hydrogels for biomedical applications

X Ding, Y Wang - Journal of Materials Chemistry B, 2017 - pubs.rsc.org
Here we define hydrogels crosslinked by weak bonds as physical hydrogels. They possess
unique features including reversible bonding, shear thinning and stimuli-responsiveness …

Injectable hydrogels

DJ Overstreet, D Dutta, SE Stabenfeldt… - Journal of Polymer …, 2012 - Wiley Online Library
Hydrogels are promising for a variety of medical applications due to their high water content
and mechanical similarity to natural tissues. When made injectable, hydrogels can reduce …

Hydrogels for therapeutic delivery: current developments and future directions

SJ Buwalda, T Vermonden, WE Hennink - Biomacromolecules, 2017 - ACS Publications
Hydrogels are attractive materials for the controlled release of therapeutics because of their
capacity to embed biologically active agents in their water-swollen network. Recent …