[Frontiers in Bioscience 10, 1835-1867, May 1, 2005] 1835 INTRACELLULAR SIGNALING
MECHANISMS OF SEX HORMONES IN ACUTE MYOCARDIAL Page 1 [Frontiers in …

Myocardial ischemia is the leading cause of death in both men and women; however, very
little information exists regarding the effect of testosterone on the response of myocardium to …

Important sex differences in the onset and characteristics of cardiovascular disease are
evident, yet the mechanistic details remain unresolved. Men are more susceptible to …

Sex differences in myocardial recovery have been reported after acute ischemia and
reperfusion injury. Estrogen and the estrogen receptor are critical determinants of …

Understanding the inflammatory response to myocardial ischemia is an important part of
achieving the elusive clinical goal of perfect myocardial protection. While it is established …

BACKGROUND: Gender differences exist in the myocardial response to acute
ischemia/reperfusion (I/R) injury and may be attributed to the effects of the sex hormones …

Cardiac rupture can be fatal after myocardial infarction (MI). Experiments in animals
revealed gender differences in rupture rate; however, patient data are controversial. We …

The myocardium generates inflammatory mediators during ischemia-reperfusion (I/R), and
these mediators contribute to cardiac functional depression and apoptosis. The great …

Chronic endogenous testosterone exposure adversely affects proinflammatory and
proapoptotic signaling after ischemia/reperfusion; however, it remains unknown whether a …

Abstract Hemorrhage, trauma, ischemia/reperfusion, burn, and sepsis each lead to cardiac
dysfunction. These insults lead to an inflammatory cascade, which plays an important role in …