Cannabidiol inhibits RAD51 and sensitizes glioblastoma to temozolomide in multiple orthotopic tumor models
L Soroceanu, E Singer, P Dighe… - Neuro-Oncology …, 2022 - academic.oup.com
Background Cannabidiol (CBD), a nonpsychoactive cannabinoid with a low toxicity profile,
has been shown to produce antitumor activity across cancers in part through selective …
has been shown to produce antitumor activity across cancers in part through selective …
Inhalant cannabidiol inhibits glioblastoma progression through regulation of tumor microenvironment
Introduction: Glioblastoma (GBM) is the most common invasive brain tumor composed of
diverse cell types with poor prognosis. The highly complex tumor microenvironment (TME) …
diverse cell types with poor prognosis. The highly complex tumor microenvironment (TME) …
A combined preclinical therapy of cannabinoids and temozolomide against glioma
S Torres, M Lorente, F Rodríguez-Fornés… - Molecular cancer …, 2011 - AACR
Glioblastoma multiforme (GBM) is highly resistant to current anticancer treatments, which
makes it crucial to find new therapeutic strategies aimed at improving the poor prognosis of …
makes it crucial to find new therapeutic strategies aimed at improving the poor prognosis of …
The Combination of Cannabidiol and Δ9-Tetrahydrocannabinol Enhances the Anticancer Effects of Radiation in an Orthotopic Murine Glioma Model
KA Scott, AG Dalgleish, WM Liu - Molecular cancer therapeutics, 2014 - AACR
High-grade glioma is one of the most aggressive cancers in adult humans and long-term
survival rates are very low as standard treatments for glioma remain largely unsuccessful …
survival rates are very low as standard treatments for glioma remain largely unsuccessful …
[HTML][HTML] The cytotoxic effects of cannabidiol and cannabigerol on glioblastoma stem cells may mostly involve GPR55 and TRPV1 signalling
TT Lah, B Majc, M Novak, A Sušnik, B Breznik… - Cancers, 2022 - mdpi.com
Simple Summary In glioblastoma (GBM), the highest-grade IV glioma, members of the large
membrane receptor family of G protein-coupled receptors (GPCRs) are upregulated …
membrane receptor family of G protein-coupled receptors (GPCRs) are upregulated …
[HTML][HTML] Cannabidiol, a non-psychoactive cannabinoid compound, inhibits proliferation and invasion in U87-MG and T98G glioma cells through a multitarget effect
M Solinas, P Massi, V Cinquina, M Valenti… - PLoS …, 2013 - journals.plos.org
In the present study, we found that CBD inhibited U87-MG and T98G cell proliferation and
invasiveness in vitro and caused a decrease in the expression of a set of proteins …
invasiveness in vitro and caused a decrease in the expression of a set of proteins …
Quantitative analyses of synergistic responses between cannabidiol and DNA-damaging agents on the proliferation and viability of glioblastoma and neural progenitor …
Evidence suggests that the nonpsychotropic cannabis-derived compound, cannabidiol
(CBD), has antineoplastic activity in multiple types of cancers, including glioblastoma …
(CBD), has antineoplastic activity in multiple types of cancers, including glioblastoma …
Cannabidiol treatment results in a common gene expression response across aggressive cancer cells from various origins
PY Desprez, R Murase, C Limbad… - Cannabis and …, 2021 - liebertpub.com
Background: We previously reported that cannabidiol (CBD), a cannabinoid with a low
toxicity profile, downregulated the expression of the prometastatic gene inhibitor of DNA …
toxicity profile, downregulated the expression of the prometastatic gene inhibitor of DNA …
[HTML][HTML] Inhibition of ATM kinase upregulates levels of cell death induced by cannabidiol and γ-irradiation in human glioblastoma cells
Despite advances in glioblastoma (GBM) therapy, prognosis of the disease remains poor
with a low survival rate. Cannabidiol (CBD) can induce cell death and enhance …
with a low survival rate. Cannabidiol (CBD) can induce cell death and enhance …
Inhibiting heat shock proteins can potentiate the cytotoxic effect of cannabidiol in human glioma cells
KA Scott, JL Dennis, AG Dalgleish, WM Liu - Anticancer research, 2015 - ar.iiarjournals.org
Cannabinoids possess a number of characteristics that make them putative anticancer
drugs, and their value as such is currently being explored in a number of clinical studies. To …
drugs, and their value as such is currently being explored in a number of clinical studies. To …