[HTML][HTML] Cannabidiol enhances cytotoxicity of anti-cancer drugs in human head and neck squamous cell carcinoma

YY Go, SR Kim, DY Kim, SW Chae, JJ Song - Scientific reports, 2020 - nature.com
Cannabidiol (CBD) has anti-tumorigenic activity. However, the anti-cancer effect of CBD on
head and neck squamous cell carcinoma (HNSCC) remains unclear. The cytotoxicity of CBD …

ACTR-56. A 2-part safety and exploratory efficacy randomised double-blind, placebo-controlled study OF A 1: 1 ratio of cannabidiol and Delta-9-tetrahydrocannabinol …

SC Short, C Little… - Neuro …, 2017 - ncbi.nlm.nih.gov
BACKGROUND Plant-derived cannabinoids have shown efficacy in GBM animal models
when co-administered with TMZ. Activation of an endoplasmic reticulum stress-related …

Cannabidiol converts NF-κB into a tumor suppressor in glioblastoma with defined antioxidative properties

MNM Volmar, J Cheng, H Alenezi, S Richter… - Neuro …, 2021 - academic.oup.com
Background The transcription factor NF-κB drives neoplastic progression of many cancers
including primary brain tumors (glioblastoma [GBM]). Precise therapeutic modulation of NF …

Cannabidiol, a non-psychoactive cannabinoid compound, inhibits human glioma cell migration and invasiveness

M Valenti, P Massi, D Bolognini, M Solinas, D Parolaro - 2009 - air.unimi.it
Malignant glioma is the most common primary brain tumor, and its high ability to invade the
surrounding brain parenchyma is a leading cause of tumor recurrence and treatment failure …

[HTML][HTML] Cannabidiol affects extracellular vesicle release, miR21 and miR126, and reduces prohibitin protein in glioblastoma multiforme cells

US Kosgodage, P Uysal-Onganer, A MacLatchy… - Translational …, 2019 - Elsevier
Glioblastoma multiforme (GBM) is the most common and aggressive form of primary
malignant brain tumor in adults, with poor prognosis. Extracellular vesicles (EVs) are key …

Cannabidiol inhibits human glioma by induction of lethal mitophagy through activating TRPV4

T Huang, T Xu, Y Wang, Y Zhou, D Yu, Z Wang, L He… - Autophagy, 2021 - Taylor & Francis
Glioma is the most common primary malignant brain tumor with poor survival and limited
therapeutic options. The non-psychoactive phytocannabinoid cannabidiol (CBD) has been …

[HTML][HTML] The Combination of Δ9-Tetrahydrocannabinol and Cannabidiol Suppresses Mitochondrial Respiration of Human Glioblastoma Cells via Downregulation of …

A Rupprecht, U Theisen, F Wendt, M Frank, B Hinz - Cancers, 2022 - mdpi.com
Simple Summary Cannabidiol (CBD) is a phytocannabinoid from Cannabis sativa L. that
exhibits no psychoactivity and, like the psychoactive cannabinoid Δ9-tetrahydrocannabinol …

[HTML][HTML] Cannabidiol and oxygen-ozone combination induce cytotoxicity in human pancreatic ductal adenocarcinoma cell lines

M Luongo, O Marinelli, L Zeppa, C Aguzzi, MB Morelli… - Cancers, 2020 - mdpi.com
Simple Summary Pancreatic cancer (PC) is related to lifestyle risks, chronic inflammation,
and germline mutations. Surgical resection and adjuvant chemotherapy are the main …

Antitumor mechanism of cannabidiol hidden behind cancer hallmarks

C Yan, Y Li, H Liu, D Chen, J Wu - … et Biophysica Acta (BBA)-Reviews on …, 2023 - Elsevier
Cannabinoids have been utilized for recreational and therapeutic purposes for over 4,000
years. As the primary ingredient in exogenous cannabinoids, Cannabidiol (CBD) has drawn …

[HTML][HTML] Regulation of human glioblastoma cell death by combined treatment of cannabidiol, γ-radiation and small molecule inhibitors of cell signaling pathways

VN Ivanov, J Wu, TK Hei - Oncotarget, 2017 - ncbi.nlm.nih.gov
Glioblastoma (GBM) is the most common primary malignant brain tumor in adults. The
challenging problem in cancer treatment is to find a way to upregulate radiosensitivity of …