THE APPLICATION OF CANNABIDIOL IN THE TREATMENT OF GLIOBLASTOMA.

A RYBARCZYK… - Acta Poloniae …, 2023 - search.ebscohost.com
Glioblastoma multiforme (GBM), a high-grade astrocytoma, is an incurable brain tumor
associated with genetic heterogeneity and dysregulated signaling pathways. As alternations …

[HTML][HTML] Modulation of the tumor microenvironment and inhibition of EGF/EGFR pathway: Novel anti-tumor mechanisms of Cannabidiol in breast cancer

M Elbaz, MW Nasser, J Ravi, NA Wani, DK Ahirwar… - Molecular …, 2015 - Elsevier
The anti-tumor role and mechanisms of Cannabidiol (CBD), a non-psychotropic cannabinoid
compound, are not well studied especially in triple-negative breast cancer (TNBC). In the …

Targeting multiple cannabinoid anti‐tumour pathways with a resorcinol derivative leads to inhibition of advanced stages of breast cancer

R Murase, R Kawamura, E Singer… - British journal of …, 2014 - Wiley Online Library
Background and Purpose The psychoactive cannabinoid Δ9‐tetrahydrocannabinol (THC)
and the non‐psychoactive cannabinoid cannabidiol (CBD) can both reduce cancer …

Triggering of the TRPV2 channel by cannabidiol sensitizes glioblastoma cells to cytotoxic chemotherapeutic agents

M Nabissi, MB Morelli, M Santoni, G Santoni - Carcinogenesis, 2013 - academic.oup.com
The aggressive behavior of Glioblastoma multiforme (GBM) is mainly due to high
invasiveness and proliferation rate as well as to high resistance to standard chemotherapy …

The antitumor action of endocannabinoids in the tumor microenvironment of glioblastoma

Y Tang, M Wang, J Yu, G Lv, Y Wang… - Frontiers in …, 2024 - frontiersin.org
Approximately 80% of all malignant brain tumors are gliomas, which are primary brain
tumors. The most prevalent subtype of glioma, glioblastoma multiforme (GBM), is also the …

Repurposing cannabidiol as a potential drug candidate for anti-tumor therapies

F Wang, G Multhoff - Biomolecules, 2021 - mdpi.com
In recent years, evidence has accumulated that cannabinoids—especially the non-
psychoactive compound, cannabidiol (CBD)—possess promising medical and …

[HTML][HTML] Cannabinoids synergize with carfilzomib, reducing multiple myeloma cells viability and migration

M Nabissi, MB Morelli, M Offidani, C Amantini… - Oncotarget, 2016 - ncbi.nlm.nih.gov
Several studies showed a potential anti-tumor role for cannabinoids, by modulating cell
signaling pathways involved in cancer cell proliferation, chemo-resistance and migration …

Bipiperidinyl Derivatives of Cannabidiol Enhance Its Antiproliferative Effects in Melanoma Cells

P Lyu, H Li, J Wan, Y Chen, Z Zhang, P Wu, Y Wan… - Antioxidants, 2024 - mdpi.com
Cannabis and its major cannabinoid cannabidiol (CBD) are reported to exhibit anticancer
activity against skin tumors. However, the cytotoxic effects of other minor cannabinoids and …

5‐Lipoxygenase and anandamide hydrolase (FAAH) mediate the antitumor activity of cannabidiol, a non‐psychoactive cannabinoid

P Massi, M Valenti, A Vaccani, V Gasperi… - Journal of …, 2008 - Wiley Online Library
It has been recently reported that cannabidiol (CBD), a non‐psychoactive cannabinoid, is
able to kill glioma cells, both in vivo and in vitro, independently of cannabinoid receptor …

Synthetic cannabinoids influence the invasion of glioblastoma cell lines in a cell-and receptor-dependent manner

T Hohmann, K Feese, T Greither, C Ghadban, V Jäger… - Cancers, 2019 - mdpi.com
The current treatment of glioblastoma is not sufficient, since they are heterogeneous and
often resistant to chemotherapy. Earlier studies demonstrated effects of specific cannabinoid …