[HTML][HTML] Balancing mitochondrial biogenesis and mitophagy to maintain energy metabolism homeostasis

K Palikaras, E Lionaki, N Tavernarakis - Cell Death & Differentiation, 2015 - nature.com
Mitochondria, the main energy hub of the cell, are highly dynamic organelles, playing
essential roles in fundamental cellular processes. Mitochondrial function impinges on …

After the banquet: mitochondrial biogenesis, mitophagy, and cell survival

J Zhu, KZQ Wang, CT Chu - Autophagy, 2013 - Taylor & Francis
Mitochondria are highly dynamic organelles of crucial importance to the proper functioning
of neuronal, cardiac and other cell types dependent upon aerobic efficiency. Mitochondrial …

[HTML][HTML] Mitochondria, autophagy and age-associated neurodegenerative diseases: new insights into a complex interplay

E Lionaki, M Markaki, K Palikaras… - Biochimica et Biophysica …, 2015 - Elsevier
Mitochondria represent the major bioenergetic hub coordinating cellular and organismal
homeostasis. The underlying causes of many pathologies tormenting humans converge on …

Mitochondrial quality control pathways as determinants of metabolic health

NM Held, RH Houtkooper - BioEssays, 2015 - Wiley Online Library
Mitochondrial function is key for maintaining cellular health, while mitochondrial failure is
associated with various pathologies, including inherited metabolic disorders and age …

Crosstalk between mitochondrial (dys) function and mitochondrial abundance

S Michel, A Wanet, A De Pauw… - Journal of cellular …, 2012 - Wiley Online Library
A controlled regulation of mitochondrial mass through either the production (biogenesis) or
the degradation (mitochondrial quality control) of the organelle represents a crucial step for …

Mitochondria in health, disease, and aging

JS Harrington, SW Ryter, M Plataki… - Physiological …, 2023 - journals.physiology.org
Mitochondria are well known as organelles responsible for the maintenance of cellular
bioenergetics through the production of ATP. Although oxidative phosphorylation may be …

[HTML][HTML] Mitochondria: in sickness and in health

J Nunnari, A Suomalainen - Cell, 2012 - cell.com
Mitochondria perform diverse yet interconnected functions, producing ATP and many
biosynthetic intermediates while also contributing to cellular stress responses such as …

Mitochondrial homeostasis: the interplay between mitophagy and mitochondrial biogenesis

K Palikaras, N Tavernarakis - Experimental gerontology, 2014 - Elsevier
Mitochondria are highly dynamic organelles and their proper function is crucial for the
maintenance of cellular homeostasis. Mitochondrial biogenesis and mitophagy are two …

[HTML][HTML] Mitochondrial quality control as a key determinant of cell survival

L Sedlackova, VI Korolchuk - … et Biophysica Acta (BBA)-Molecular Cell …, 2019 - Elsevier
Mitochondria are the energy producing dynamic double-membraned organelles essential
for cellular and organismal survival. A multitude of intra-and extra-cellular signals involved in …

Signaling pathways in mitochondrial dysfunction and aging

C Mammucari, R Rizzuto - Mechanisms of ageing and development, 2010 - Elsevier
Mitochondria are central players in the determination of cell life and death. They are
essential for energy production, since most cellular ATP is produced in their matrix by the …