In contrast to large proteins, small peptide catalysts typically display limited specificity for
small molecule substrates. This is presumably a result of the limited opportunities small …

Enzymes' machinery has been an inspiration for chemists. Peptides are vital players in the
origin of life, being ancestors of complex enzymes. Even short peptides that are simple in …

Publisher Summary This chapter describes the available techniques for multiple and library
synthesis of peptides. It focuses on synthetic techniques that can be immediately applied in …

Publisher Summary The practical use of nonsupport-bound combinatorial libraries
represents an important breakthrough in all the areas of basic research and drug discovery …

Combinatorial preparation and HTS of arrays of compounds have increased the speed of
drug discovery. A strong impulse in this field has come by the introduction of the solid phase …

Small (24− 35 amino acid residues) peptides that catalyze carbon− carbon bond
transformations including aldol, retro-aldol, and Michael reactions in aqueous buffer via an …

The total synthesis, at will, of a wide variety of protein and enzyme molecules is made
feasible by modern chemical ligation methods. As Emil Fischer intuitively understood …

We sought to develop a peptide library in solution and dynamically screen this library for
peptides that would bind to macromolecules of interest. Peptide diversity was achieved in an …

The synthesis of large numbers of peptides can be very labor intensive and, if a
conventional peptide synthesizer is used, only small numbers of peptides can be produced …

While the elegance and efficiency of enzymatic catalysis have long tempted chemists and
biochemists with reductionist leanings to try to mimic the functions of natural enzymes in …